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Gene Mapping, Cloning and Sequencing

Molecular cloning of a human novel type I cytokine receptor related to δ1/TSLPR

Tonozuka Y.a · Fujio K.a · Sugiyama T.a · Nosaka T.a · Hirai M.b · Kitamura T.a

Author affiliations

aDivision of Hematopoietic Factors, Advanced Clinical Research Center, Institute of Medical Science, and bDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo (Japan)

Related Articles for ""

Cytogenet Cell Genet 93:23–25 (2001)

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Article / Publication Details

First-Page Preview
Abstract of Gene Mapping, Cloning and Sequencing

Published online: July 19, 2001
Issue release date: 2001

Number of Print Pages: 3
Number of Figures: 5
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

In a search for a human sequence related to a recently identified type I cytokine receptor δ1, which turned out to be a receptor subunit for a cytokine called TSLP, we have now identified a novel human type I cytokine receptor from a human T lymphocyte cDNA library. The deduced amino acid sequence of 371 residues has a typical signal sequence and a membrane-spanning region. The mature protein is predicted to have a molecular mass of 39,698 Da. The N-terminal extracellular region contains two fibronectin type III-like domains, four conserved cysteine residues, and a WSXWS box-like motif. The C-terminal intracellular region contains box 1 and box 2-like motifs. Thus, it has common characteristics of type I cytokine receptor family members, and we tentatively termed this protein CRLF2, which stands for cytokine receptor-like factor 2. Northern blot analysis revealed CRLF2 mRNA in liver, kidney, heart, and skeletal muscle. The fetal liver also expresses CRLF2 transcripts. The gene for CRLF2 was mapped to the pseudoautosomal region, Xp22.3 and Yp11.3 by FISH analysis, a region where genes encoding the IL-3 receptor α and the GM-CSF receptor α chains are also located. The biological function of this newly identified receptor is now under investigation.   

© 2001 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Gene Mapping, Cloning and Sequencing

Published online: July 19, 2001
Issue release date: 2001

Number of Print Pages: 3
Number of Figures: 5
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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