The deoxynucleotide carrier (DNC) transports deoxynucleotides into mitochondria and is therefore essential for mtDNA synthesis. The human DNC gene (SLC25A19) spans about 16.5 kb and consists of nine exons with the translation start site in exon 4. It is located on chromosome 17q25.3. Three transcripts, which differ in their 5′ ends and are generated by alternative splicing, have been identified.
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Supported in part by AIRC, MURST-PRIN, MURST L.488/92 C03 and C04, MURST 5%-CNR L. 95/95, CNR target project on “Biotechnology”, and the European Social Fund. The financial support of Telethon, Italy (grant E.672 and grant E.0958) is gratefully acknowledged.
Received: Received 7 February 2001;
manuscript accepted 29 March 2001.
Number of Print Pages : 3
Number of Figures : 3, Number of Tables : 1, Number of References : 12
Cytogenetics and Cell Genetics
Founded 1962 as Cytogenetics by H.P. Klinger
Vol. 93, No. 1-2, Year 2001 (Cover Date: 2001)
Journal Editor: H.P. Klinger, Bronx, N.Y.; M. Schmid, Würzburg
ISSN: 0301–0171 (print), 1422–9816 (Online)
For additional information: http://www.karger.com/journals/ccg
Article / Publication Details
Published online: 7/19/2001
Issue release date: 2001
Number of Print Pages: 3
Number of Figures: 3
Number of Tables: 1
ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)
For additional information: http://www.karger.com/CGR
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