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Table of Contents
Vol. 93, No. 3-4, 2001
Issue release date: 2001
Section title: Gene Mapping, Cloning and Sequencing
Cytogenet Cell Genet 93:234–238 (2001)
(DOI:10.1159/000056989)

Genomic structure and chromosome location of the human gene encoding the zinc finger autoantigen ZNF330

Bolívar J. · García-Cozar F.J. · Astola A. · Iglesias C. · Pendón C. · Valdivia M.M.
Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Cádiz, Cádiz (Spain)

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Article / Publication Details

First-Page Preview
Abstract of Gene Mapping, Cloning and Sequencing

Published online: August 23, 2001
Issue release date: 2001

Number of Print Pages: 5
Number of Figures: 4
Number of Tables: 1

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

We have recently described a novel zinc finger cDNA, ZNF330, which was immunologicaly characterized as a new human autoantigen, highly conserved during evolution from nematodes to humans. The protein was found at the nucleolus and the cytoplasm in interphase and transiently associates with centromeres in mitosis as determined by immunofluorescence analysis. We now describe that the association of ZNF330 with the nucleolus but not with the cytoplasm is RNA-dependent as shown by RNAse treatment of fixed culture cells, since ZNF330 localization was unaffected by DNAse treatment. We also report the cloning, structural organization and chromosome location of the human ZNF330 gene. The gene is comprised of 10 exons and spans approximately 16 kb of genomic DNA. The conserved residues forming nine CXXC motifs are contained in exons 3 to 9. Several major transcription initiation sites were located 126, 124 and 121 bp upstream of the translation initiation codon ATG, as determined by primer extension analysis. The human ZNF330 gene was mapped by FISH to chromosome 4q31.1→q31.2, the site of the FRA4C locus previously described as a common fragile site for acquired chromosome instability in humans.   

© 2001 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Gene Mapping, Cloning and Sequencing

Published online: August 23, 2001
Issue release date: 2001

Number of Print Pages: 5
Number of Figures: 4
Number of Tables: 1

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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