Prostanoid Signal Integration and Cross TalkWise H. · Wong Y.H. · Jones R.L.
aDepartment of Pharmacology, Faculty of Medicine, Chinese University of Hong Kong and bDepartment of Biochemistry and Biotechnology Research Institute, Hong Kong University of Science and Technology, Hong Kong, China
The enzymatic machinery for the production of prostanoids and the receptors responsible for detecting their presence are widely distributed in the body. One pair of prostanoids, prostacyclin and thromboxane A2, are particularly important in the control of haemodynamics and haemostasis. Prostacyclin achieves its antiplatelet effect by acting as a physiological antagonist, but displays some selectivity towards thromboxane A2-mediated platelet activation, possibly by virtue of the inability of thromboxane A2 receptors to couple directly to Gi proteins, and because platelet-derived endoperoxides can act as substrates for prostacyclin synthesis in endothelial cells. At low concentrations, prostaglandin E2 can synergize with thromboxane A2 by acting on the EP3 subtype of prostaglandin E2 receptor, resulting in opposition to the protective function of prostacyclin. In contrast, high concentrations of prostaglandin E2 act on the prostacyclin receptor, and possibly the prostaglandin D2 receptor, to turn off platelet activation. Integration of prostanoid signalling in the vascular system is similarly complex, and interpretation of data is further complicated by the regional distribution of prostanoid receptors in different vascular beds, and the poor selectivity of agonists and antagonists.
Dr. Helen Wise
Department of Pharmacology, Faculty of Medicine
Chinese University of Hong Kong
Hong Kong SAR (China)
Tel. +852 2609 6849, Fax +852 2603 5139, E-Mail firstname.lastname@example.org
Number of Print Pages : 9
Number of Figures : 2, Number of Tables : 0, Number of References : 63
Founded 1992 as ‘Biological Signals’ by S.F. Pang (1992–2001) continued as ‘Biological Signals and Receptors’ (1999–2001)
Vol. 11, No. 1, Year 2002 (Cover Date: January-February 2002)
Journal Editor: Nancy Y. Ip, Hong Kong
ISSN: 1424–862X (print), 1424–8638 (Online)
For additional information: http://www.karger.com/journals/nsg