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Vol. 75, No. 5, 2002
Issue release date: May 2002
Section title: Central Effects of Gonadal Hormones
Neuroendocrinology 2002;75:282–287
(DOI:10.1159/000057337)

Ovarian Hormones Do Not Attenuate Methamphetamine-Induced Dopaminergic Neurotoxicity in Mice Gonadectomized at 4 Weeks Postpartum

Yu L. · Kuo Y. · Cherng C.G. · Chen H.-H. · Hsu C.-H.
aInstitute of Behavioral Medicine, and bDepartment of Anatomy, National Cheng Kung University College of Medicine, Tainan, cPsychological Research Center, ROC Air Force Academy, Kangshan, and dDepartment of Psychology, National Taiwan University, Taipei, Taiwan

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Article / Publication Details

First-Page Preview
Abstract of Central Effects of Gonadal Hormones

Published online: 4/29/2002

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN

Abstract

The present study was undertaken to assess the ability of ovarian hormones to alter methamphetamine (MA)-induced dopaminergic toxicity in male and female mice gonadectomized at 4 and 6 weeks of age. None of the following three treatments, estradiol benzoate (EB, 3 × 0.47 µg), progesterone (Prog, 3 × 0.47 µg), or EB (2 × 0.47 µg) followed by Prog (0.47 µg), affected the dopamine (DA)-depleting effects of MA in male and female mice gonadectomized when they were 4 weeks old. However, in contrast to the findings that male mice are more sensitive to MA-induced DA depletion than female mice, no sexual differences in the sensitivity to MA treatment were observed in mice gonadectomized at this age. Moreover, three daily doses of EB (0.47 µg) and EB (0.47 µg) combined with 4-hydroxytamoxifen (4OHT, 6 µg) effectively attenuated striatal DA depletion produced by MA in female mice ovariectomized at 6 weeks of age. Three daily doses of Prog (0.47 µg) and EB (0.47 µg) combined with 4OHT (6 µg) significantly attenuated MA-induced striatal DA depletion in male mice gonadectomized at 6 weeks of age. Taken together, the modulating effects of ovarian hormones on MA-induced DA depletion in mouse striatum could be sex- and age-dependent. 4OHT did not block the protecting effects of EB on MA-induced DA depletion in female and male mice, suggesting that the estrogen receptor may not be involved in the protective effects of EB on attenuating MA-induced DA toxicity.


  

Author Contacts

Lung Yu
National Cheng Kung University College of Medicine
Institute of Behavioral Medicine
1 University Rd, Tainan 70101 (Taiwan)
Tel. +886 6 2353535, ext. 5114, Fax +886 6 2084280, E-Mail lungyu@mail.ncku.edu.tw

  

Article Information

Received: Received: June 7, 2001
Accepted after revision: December 17, 2001
Number of Print Pages : 6
Number of Figures : 4, Number of Tables : 0, Number of References : 24

  

Publication Details

Neuroendocrinology (International Journal for Basic and Clinical Studies on Neuroendocrine Relationships)
Founded 1965 by E. Bajusz. Continued by K.M. Knigge (1973–1978), W.F. Ganong (1979–1984), S.M. McCann (1985–1993)

Vol. 75, No. 5, Year 2002 (Cover Date: May 2002)

Journal Editor: C. Kordon, Paris
ISSN: 0028–3835 (print), 1423–0194 (Online)

For additional information: http://www.karger.com/journals/nen


Article / Publication Details

First-Page Preview
Abstract of Central Effects of Gonadal Hormones

Published online: 4/29/2002

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN


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