Journal Mobile Options
Table of Contents
Vol. 25, No. 3, 1999
Issue release date: May–June 1999
Section title: Original Paper
Miner Electrolyte Metab 1999;25:143–146
(DOI:10.1159/000057438)

Adequate Dietary Calcium Mitigates Osteopenia Induced by Chronic Lead Exposure in Adult Rats

Gruber H.E. · Ding Y. · Stasky A.A. · Meyer M. · Pandian M.R. · Pandian D. · Vaziri N.D. · Grigsby J. · Gonick H.C.
aDepartment of Orthopaedic Surgery, Carolinas HealthCare System, Charlotte, N.C. bDepartment of Medicine, University of California, Irvine, Calif. cCorning Nichols Institute Laboratory, Corning, N.Y. dDepartment of Biostatistics, Carolinas HealthCare System, charlotte, N.C. eDepartment of Medicine, Cedars-Sinai Medical Center, and Department of Medicine, UCLA Center for Health Sciences, Los Angeles, Calif., and University of California, Irvine, Calif., USA

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 33.00
Account: USD 23.00

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 7/14/1999
Issue release date: May–June 1999

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 2

ISSN: 0378-0392 (Print)
eISSN: 1423-016X (Online)

For additional information: http://www.karger.com/MEM

Abstract

The purpose of the present study was to investigate bone changes in the adult rat exposed to low lead levels during intake of normal dietary calcium and to contrast these findings with data from our earlier studies performed with animals receiving low dietary calcium concurrent with lead exposure. The present study exposed adult rats to 100 ppm lead via drinking water for 12 weeks and assessed bone histology, 1,25-dihydroxyvitamin D, 25(OH)vitamin D and parathyroid hormone levels. No osteopenia was evident by quantitative bone histology, and circulating levels of 1,25-dihydroxyvitamin D, 25(OH) vitamin D and parathyroid hormone were normal. Bone ash findings documented incorporation of significant amounts of lead into bone mineral. These findings document absence of interference with vitamin D metabolism, absence of secondary hyperparathyroidism and absence of osteopenia following 12 weeks of low lead exposure in the adult rat maintained on normal calcium intake. Results stress the importance of adequate calcium intake in our elderly population who may be exposed to cumulative, low-level lead exposure.


  

Author Contacts

Helen E. Gruber, PhD
Orthopaedic Research Biology
Carolinas HealthCare System, PO Box 32861
Charlotte, NC 28232 (USA)
Tel. +1 704/355 5658, Fax +1 704/355 2845, E‐Mail hgruber@carolinas.org

  

Article Information



Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 2, Number of References : 16

  

Publication Details

Mineral and Electrolyte Metabolism

Vol. 25, No. 3, Year 1999 (Cover Date: May-June 1999)

Journal Editor: Shaul G. Massry, Los Angeles, Calif.
ISSN: 0378–0392 (print), 1423–016X (Online)

For additional information: http://www.karger.com/journals/mem


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 7/14/1999
Issue release date: May–June 1999

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 2

ISSN: 0378-0392 (Print)
eISSN: 1423-016X (Online)

For additional information: http://www.karger.com/MEM


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.