Adequate Dietary Calcium Mitigates Osteopenia Induced by Chronic Lead Exposure in Adult RatsGruber H.E.a · Ding Y.b · Stasky A.A.a · Meyer M.a · Pandian M.R.c · Pandian D.b · Vaziri N.D.b · Grigsby J.d · Gonick H.C.e
aDepartment of Orthopaedic Surgery, Carolinas HealthCare System, Charlotte, N.C. bDepartment of Medicine, University of California,
The purpose of the present study was to investigate bone changes in the adult rat exposed to low lead levels during intake of normal dietary calcium and to contrast these findings with data from our earlier studies performed with animals receiving low dietary calcium concurrent with lead exposure. The present study exposed adult rats to 100 ppm lead via drinking water for 12 weeks and assessed bone histology, 1,25-dihydroxyvitamin D, 25(OH)vitamin D and parathyroid hormone levels. No osteopenia was evident by quantitative bone histology, and circulating levels of 1,25-dihydroxyvitamin D, 25(OH) vitamin D and parathyroid hormone were normal. Bone ash findings documented incorporation of significant amounts of lead into bone mineral. These findings document absence of interference with vitamin D metabolism, absence of secondary hyperparathyroidism and absence of osteopenia following 12 weeks of low lead exposure in the adult rat maintained on normal calcium intake. Results stress the importance of adequate calcium intake in our elderly population who may be exposed to cumulative, low-level lead exposure.
Helen E. Gruber, PhD
Orthopaedic Research Biology
Carolinas HealthCare System, PO Box 32861
Charlotte, NC 28232 (USA)
Tel. +1 704/355 5658, Fax +1 704/355 2845, E‐Mail firstname.lastname@example.org
Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 2, Number of References : 16
Mineral and Electrolyte Metabolism
Vol. 25, No. 3, Year 1999 (Cover Date: May-June 1999)
Journal Editor: Shaul G. Massry, Los Angeles, Calif.
ISSN: 0378–0392 (print), 1423–016X (Online)
For additional information: http://www.karger.com/journals/mem