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Vol. 107, No. 3, 2002
Issue release date: April 2002
Section title: Original Paper
Acta Haematol 2002;107:145–149
(DOI:10.1159/000057632)

Relationship of Body Iron Stores to Levels of Serum Ferritin, Serum Iron, Unsaturated Iron Binding Capacity and Transferrin Saturation in Patients with Iron Storage Disease

Beutler E. · Felitti V. · Ho N.J. · Gelbart T.
aThe Scripps Research Institute, La Jolla, Calif., and bKaiser Permanente, Department of Preventive Medicine, SanDiego, Calif., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 4/25/2002

Number of Print Pages: 5
Number of Figures: 4
Number of Tables: 2

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA

Abstract

None of the methods for assessing total body iron burden in patients with hemochromatosis is satisfactory. Although it is commonly believed that a relationship exists between serum ferritin levels and total iron burden, the extent of this relationship has not previously been documented. In the present investigation we measured the total body iron burden of 88 patients with putative hemochromatosis, 54 of whom were homozygotes for the 845G→A (C282Y) mutation. The total body iron stores were estimated from the volume of red cells removed during therapeutic phlebotomy corrected for an estimated 2 mg/day dietary iron absorbed during the phlebotomy period; the amount of storage iron was compared to the serum ferritin, serum iron, unsaturated iron binding capacity, and transferrin saturation before the beginning of phlebotomy. The serum ferritin proved to be the best predictor of body iron stores. The correlation between all of the analytes and the body iron burden was greater in patients homozygous for the C282Y mutation than in those who were not, including the compound heterozygotes for C282Y and H63D. The body iron burden tended to be greater in patients homozygous for the C282Y mutation than the other patients at any other given ferritin level. We conclude that the serum ferritin level does provide some information regarding total iron burden but even in the case of C282Y homozygotes, the correlation is not very strong.


  

Author Contacts

Prof. E. Beutler
The Scripps Research Institute
10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Tel. +1 858 784 8040, Fax +1 858 784 2083
E-Mail beutler@scripps.edu

  

Article Information

Received: Received: August 10, 2001
Accepted: August 31, 2001
Number of Print Pages : 5
Number of Figures : 4, Number of Tables : 2, Number of References : 15

  

Publication Details

Acta Haematologica
Founded 1948
Affiliated with Molecular Biology of Hematopoiesis Symposium

Vol. 107, No. 3, Year 2002 (Cover Date: Released April 2002)

Journal Editor: I. Ben-Bassat, Tel Hashomer
ISSN: 0001–5792 (print), 1421–9662 (Online)

For additional information: http://www.karger.com/journals/aha


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 4/25/2002

Number of Print Pages: 5
Number of Figures: 4
Number of Tables: 2

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


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