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Vol. 7, No. 2, 2002
Issue release date: March–April 2002
Section title: Original Paper
Audiol Neurootol 2002;7:100–106
(DOI:10.1159/000057657)

Nongenomic Effects of Corticosteroids on Ion Transport by Stria vascularis

Lee J.H. · Marcus D.C.
Kansas State University, Department of Anatomy and Physiology, Manhattan, Kans., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 4/26/2002
Issue release date: March–April 2002

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 1

ISSN: 1420-3030 (Print)
eISSN: 1421-9700 (Online)

For additional information: http://www.karger.com/AUD

Abstract

Stria vascularis electrogenically secretes potassium into endolymph and this secretion is known to be under acute control of several hormone receptors including purinergic, adrenergic and muscarinic receptors. Recently, chronic application of glucocorticosteroid hormones in autoimmune mice was reported to restore both hearing and normal strial morphology. The purpose of this study was to investigate the acute nongenomic effects of glucocorticoids and mineralocorticoid on the short circuit current (Isc,probe) across isolated stria vascularis of gerbils using the voltage-sensitive vibrating probe. Application of prednisolone (0.1–30 µM) caused an increase of Isc,probe in a dose-dependent manner with an EC50 of 1.1 ± 0.2 µM (n = 5). Hydrocortisone (10 µM, n = 5) and dexamethasone (10 µM, n = 5) also increased Isc,probe, but the response was transient and the response rate was faster than for prednisolone. By contrast, aldosterone (10 µM, n = 6) caused a transient decrease of Isc,probe within seconds. These results suggest that prednisolone increased secretion of K+ via a nongenomic mechanism in the range of therapeutic plasma concentrations and that this stimulatory effect of glucocorticoids is specific since the mineralocorticoid aldosterone caused a distinctly different response.


  

Author Contacts

Daniel C. Marcus, DSc
Kansas State University, Anatomy and Physiology
126 Coles Hall, 1600 Denison Ave.
Manhattan, KS 66506-5802 (USA)
Tel. +1 785 532 4532, Fax +1 785 532 4557, E-Mail marcus@ksu.edu

  

Article Information

Received: Received: May 18, 2001
Accepted after revision: July 20, 2001
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 1, Number of References : 39

  

Publication Details

Audiology & Neuro-Otology (Basic Research and Clinical Applications)

Vol. 7, No. 2, Year 2002 (Cover Date: March-April 2002)

Journal Editor: Manfried Hoke, Münster, Germany
ISSN: 1420–3030 (print), 1421–9700 (Online)

For additional information: http://www.karger.com/journals/aud


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 4/26/2002
Issue release date: March–April 2002

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 1

ISSN: 1420-3030 (Print)
eISSN: 1421-9700 (Online)

For additional information: http://www.karger.com/AUD


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