Recombinant Marker Allergens: Diagnostic Gatekeepers for the Treatment of AllergyKazemi-Shirazi L. · Niederberger V. · Linhart B. · Lidholm J. · Kraft D. · Valenta R.
aDivision of Gastroenterology and Hepatology, Department of Internal Medicine IV, bDepartment of Pathophysiology and cDepartment of Otorhinolaryngology, University of Vienna, Austria; dPharmacia Diagnostics, Uppsala, Sweden
During the past decade an increasing number of recombinant allergens have become available, representing a significant proportion of the epitope complexity of natural allergen extracts. Component-resolved diagnosis with recombinant allergens reveals the antibody reactivity profile of allergic patients and identifies the disease-eliciting allergen molecules. This article exemplifies how recombinant allergen molecules with high cross-reactive potential can be used as marker allergens to identify allergic patients who are cross-sensitized to a variety of allergen sources. It further demonstrates how the use of allergens with a restricted distribution in a certain group of allergen sources may allow the identification of patients who have been genuinely sensitized by a particular allergen molecule. Drawing from those examples, it is suggested how diagnostic tests based on such recombinant marker allergens may be used to improve the choice and monitoring of currently available forms of specific immunotherapy.
Correspondence to: Prof. Dr. Rudolf Valenta
Molecular Immunopathology Group
Department of Pathophysiology, University of Vienna Medical School
Vienna General Hospital, Waehringer Gürtel 18–20, A–1090 Vienna (Austria)
Tel. +43 1 40400 5108, Fax +43 1 40400 5130, E-Mail Rudolf.Valenta@akh-wien.ac.at
L.K.-S. and V.N. contributed equally.
Number of Print Pages : 10
Number of Figures : 4, Number of Tables : 0, Number of References : 82
International Archives of Allergy and Immunology
Vol. 127, No. 4, Year 2002 (Cover Date: April 2002)
Journal Editor: D. Kraft, Vienna
ISSN: 1018–2438 (print), 1423–0097 (Online)
For additional information:http://www.karger.com/journals/iaa