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Vol. 65, No. 3, 2002
Issue release date: July 2002
Section title: Original Paper
Pharmacology 2002;65:170–174
(DOI:10.1159/000058044)

Protective Effect of Resveratrol against Pentylenetetrazole-Induced Seizures and Its Modulation by an Adenosinergic System

Gupta Y.K. · Chaudhary G. · Srivastava A.K.
Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 6/5/2002
Issue release date: July 2002

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 1

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA

Abstract

The effect of trans-resveratrol (resveratrol), a polyphenolic compound with potent antioxidant activity, was investigated against pentylenetetrazole (PTZ) induced seizures in rats. Resveratrol (20, 40, and 80 mg/kg i.p.) administered 20 min prior to convulsive challenge with PTZ (60 mg/kg i.p.) dose dependently reduced the percent incidence of generalized tonic-clonic convulsions. Resveratrol (40 mg/kg) also potentiated the effect of sodium valproate (150 mg/kg) and diazepam (2 mg/kg) against PTZ-induced seizures. Since adenosine, an endogenous anticonvulsant, has been demonstrated to modulate the action of various antiepileptics, experiments were also carried out to determine whether an adenosinergic mechanism is involved in the anticonvulsant action of resveratrol. When a subanticonvulsant dose of adenosine (500 mg/kg) was administered together with resveratrol, a significant reduction in the percent incidence of generalized tonic-clonic convulsions was observed. Moreover, the nonspecific adenosine receptor antagonist theophylline (50 mg/kg i.p.) significantly reversed the resveratrol-induced protection, whereas the specific adenosine A2 receptor antagonist 3,7-dimethyl-1-propargylxanthine (1 mg/kg i.p.) could not reverse the resveratrol-induced protection. The findings of the present study suggest an antiepileptic potential of resveratrol and that an adenosinergic mechanism may play a role in its anticonvulsant activity.

© 2002 S. Karger AG, Basel


  

Author Contacts

Prof. Y.K. Gupta
Department of Pharmacology
All India Institute of Medical Sciences
New Delhi 110029 (India)
Tel. +91 6593684, Fax +91 6864789, E-Mail ykg@hotmail.com

  

Article Information

Received: Received: August 13, 2001
Accepted: November 7, 2001
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 1, Number of References : 11

  

Publication Details

Pharmacology (International Journal of Experimental and Clinical Pharmacology)
Founded 1959 as ‘Medicina Experimentalis’, continued 1965–1967 as ‘Medicina et Pharmacologia Experimentalis’; Founder: R. Domenjoz (1959–1977); Successors: B.B. Brodie (1968–1977); K. Lederis (1973–1985); K.-F. Sewing (1978–1998); E.S. Vesell (1970–2000)

Vol. 65, No. 3, Year 2002 (Cover Date: July 2002)

Journal Editor: J. Donnerer, Graz; M.L. Billingsley, Hershey, Pa.; T. Watanabe, Sendai; T. Iijima, Akita
ISSN: 0031–7012 (print), 1423–0313 (Online)

For additional information: http://www.karger.com/journals/pha


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 6/5/2002
Issue release date: July 2002

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 1

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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