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Table of Contents
Vol. 128, No. 2, 2002
Issue release date: June 2002
Section title: Original Paper
Int Arch Allergy Immunol 2002;128:136–141
(DOI:10.1159/000059404)

Serum Tryptase Levels in Patients with Mastocytosis: Correlation with Mast Cell Burden and Implication for Defining the Category of Disease

Sperr W.R.a · Jordan J.-H.a · Fiegl M.c · Escribano L.e · Bellas C.f · Dirnhofer S.d · Semper H.a · Simonitsch-Klupp I.b · Horny H.-P.g · Valent P.a
aDepartment of Internal Medicine I, Division of Hematology and Hemostaseology, bDepartment of Clinical Pathology, University of Vienna, cDepartment of Internal Medicine, Division of Hematology, dInstitute of Pathology, University of Innsbruck, Austria; eServicio de Hematologia, Unidad de Mastocitosis, fServicio de Anatomia Patológica, Hospital Ramón y Cajal, Madrid, España; gInstitute of Pathology, Medical University of Lübeck, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: June 13, 2002
Issue release date: June 2002

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Background: The serum tryptase level is used as a diagnostic marker in mastocytosis and is considered to reflect the burden of (neoplastic) mast cells (MC). Methods: In the present study, serum tryptase levels were measured in patients with mastocytosis by fluoroenzyme immunoassay and compared with the extent of infiltration of the bone marrow (BM) by neoplastic MC, determined by tryptase immunohistochemistry. Sixteen patients with cutaneous mastocytosis (CM) and 43 patients with systemic mastocytosis (SM) were examined. Results: In most patients with CM (defined by the absence of dense compact MC infiltrates in tryptase-stained BM sections), normal or near-normal serum tryptase levels (median 10 ng/ml, range 2–23 ng/ml) were measured. By contrast, in the vast majority of patients with SM, elevated serum tryptase levels (median 67 ng/ml) were found. In addition, there was a significant correlation between the grade of infiltration of the BM by neoplastic MC and tryptase levels in patients with SM (r = 0.8). Moreover, enzyme levels differed significantly among the groups of patients with different types of SM. The highest levels (>900 ng/ml) were detected in the patient with MC leukemia, 2 patients with slowly progressing SM and high MC burden (smoldering SM) and 1 patient with indolent SM. In contrast, in all 3 patients with isolated BM mastocytosis (no skin lesions and no signs of multiorgan involvement), serum tryptase levels were <20 ng/ml. Conclusions: In summary, our data suggest that the measurement of serum tryptase is a reliable noninvasive diagnostic approach to estimate the burden of MC in patients with mastocytosis and to distinguish between categories of disease.

© 2002 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: June 13, 2002
Issue release date: June 2002

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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