Chromosome painting refines the history of genome evolution in hares and rabbits (order Lagomorpha)Robinson T.J. · Yang F. · Harrison W.R.
aDepartment of Zoology, University of Stellenbosch, Stellenbosch (South Africa) bCentre for Veterinary Science, University of Cambridge, Cambridge (UK) cKunming Institute of Zoology, The Chinese Academy of Sciences, Yunnan (People’s Republic of China)
Fluorescence in situ hybridization (FISH) was used to define homologous segments among representatives of 7 of the 11 recognized leporid genera. Chromosome painting using 22 rabbit chromosome-specific paints derived from flow-sorted chromosomes revealed that at least 18 fusions and six fissions differentiate the extant karyotypes from the presumed ancestral state (2n = 48). The riverine rabbit, Bunolagus monticularis, has the most derived karyotype, differing from the ancestor by seven fusions and five fissions, followed by Pronolagus rupestris, with four fusions and one fission. These findings are consistent with the proposed Palaeolaginae/Leporinae dichotomy in the lagomorphs. The molecular cytogenetic data allow for a refinement of the structural changes that have shaped genome evolution in this group of mammals and underscore the rapid radiation of the Leporidae suggested by mitochondrial DNA sequence data.
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This article is dedicated to Professor Karl Fredga to commemorate his retirement and lifelong cytogenetic research activities.
Supported by the South African National Research Foundation (T.J.R.).
Received: Received 28 January 2002;
revision accepted 7 March 2002.
Number of Print Pages : 5
Number of Figures : 2, Number of Tables : 1, Number of References : 37
Cytogenetic and Genome Research
Formerly ‘Cytogenetics and Cell Genetics’
Vol. 96, No. 1-4, Year 2002 (Cover Date: 2002)
Journal Editor: H.P. Klinger, Bronx, N.Y.; M. Schmid, Würzburg
ISSN: 1424–8581 (print), 1424–859X (Online)
For additional information: http://www.karger.com/journals/cgr