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Vol. 82, No. 2, 2002
Issue release date: August 2002
Section title: Original Paper
Biol Neonate 2002;82:103–108
(DOI:10.1159/000063096)

Probiotics Feeding in Prevention of Urinary Tract Infection, Bacterial Sepsis and Necrotizing Enterocolitis in Preterm Infants

A Prospective Double-Blind Study

Dani C. · Biadaioli R. · Bertini G. · Martelli E. · Rubaltelli F.F.
Department of Surgical and Medical Critical Care, Division of Neonatology, Careggi University Hospital, Florence, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/27/2002
Published online: 8/7/2002

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO

Abstract

Background: It has been suggested that probiotics can reduce the overgrowth of pathogens in the bowels of preterm infants and contribute to the reduction of the incidence of nosocomial infections in neonatal intensive care units (NICUs). The purpose of this study was to evaluate the effectiveness of Lactobacillus GG supplementation in reducing the incidence of urinary tract infections (UTIs), bacterial sepsis and necrotizing enterocolitis (NEC) in preterm infants. Methods: A double-blind study was conducted in 12 Italian NICUs. Newborn infants with a gestational age <33 weeks or birthweight <1,500 g were randomized to receive standard milk feed supplemented with Lactobacillus GG (Dicoflor®, Dicofarm, Rome, Italy) in a dose of 6 × 109 colony-forming units (cfu) once a day until discharge, starting with the first feed or placebo. Results: Five hundred eighty-five patients were studied. The probiotics group (n = 295) and the placebo group (n = 290) exhibited similar clinical characteristics. The duration of Lactobacillus GG and placebo supplementation was 47.3 ± 26.0 and 48.2 ± 24.3 days, respectively. Although UTIs (3.4 vs. 5.8%) and NEC (1.4 vs. 2.7%) were found less frequently in the probiotic group compared to the control group, these differences were not significant. Bacterial sepsis was more frequent in the probiotics group (4.4%, n = 11) than in the placebo group (3.8%, n = 9), but the difference was not significant. Conclusion: Seven days of Lactobacillus GG supplementation starting with the first feed is not effective in reducing the incidence of UTIs, NEC and sepsis in preterm infants. Further studies are required to confirm our results in lower birthweight populations.


  

Author Contacts

Carlo Dani, MD
Division of Neonatology
Careggi University Hospital of Florence
Viale Morgagni 85, I–50134 Florence (Italy)
Tel. +39 055 4277428, Fax +39 055 412900, E-Mail cdani@unifi.it

  

Article Information

Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 3, Number of References : 40

  

Publication Details

Biology of the Neonate (Foetal and Neonatal Research)

Vol. 82, No. 2, Year 2002 (Cover Date: Released August 2002)

Journal Editor: J.P. Relier, Paris
ISSN: 0006–3126 (print), 1421–9727 (Online)

For additional information: http://www.karger.com/journals/bon


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/27/2002
Published online: 8/7/2002

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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