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Vol. 46, No. 1, 2002
Issue release date: August 2002
Section title: Biological Psychiatry. Main Editor: J. Mendlewicz (Brussels) / Original Paper
Neuropsychobiology 2002;46:27–32
(DOI:10.1159/000063573)

Antioxidant Enzyme Activities and Malondialdehyde Levels in Patients with Obsessive-Compulsive Disorder

Kuloglu M.a · Atmaca M.a · Tezcan E.a · Gecici Ö.a · Tunckol H.a · Ustundag B.b
Departments of aPsychiatry and bBiochemistry, Medical Faculty, Firat University, Elazig, Turkey

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Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Main Editor: J. Mendlewicz (Brussels) / Original Paper

Published online: 8/23/2002
Issue release date: August 2002

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

To examine the importance of free radicals in the pathogenesis of obsessive-compulsive disorder (OCD), we aimed to evaluate whether malondialdehyde (MDA), a product of lipid peroxidation, and antioxidant enzyme [superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT)] activity levels were associated with OCD. The patients were divided into two subgroups according to whether DSM-IV major depressive disorder (MDD) was accompanied (OCD + MDD) or not (OCD – MDD). The MDA and antioxidant enzyme levels both in patients and controls were determined. SOD activity levels were significantly higher in the OCD + MDD group compared with the control and the OCD – MDD group. Although the OCD – MDD group had slightly higher SOD activity levels as compared with the controls, the difference was not statistically significant. GSH-Px activity levels were statistically significantly higher in both groups compared with controls. Likewise, there was a significant difference in GSH-Px activity levels between the OCD + MDD and OCD – MDD group. CAT activity levels were slightly higher in the OCD + MDD group compared with the OCD – MDD and control group. MDA levels in both groups were significantly higher than in controls. In addition, the difference in MDA levels between both groups was statistically significant. In conclusion, our results suggest that OCD is associated with free radicals and that it may be a heterogeneous subtype including some biological indications of anxiety and affective disorders. More comprehensive and detailed studies are needed to decipher the exact role of free radicals in OCD.

© 2002 S. Karger AG, Basel


  

Author Contacts

Dr. Murat Kuloglu
Firat (Euphrates) Üniversitesi, Firat Tip Merkezi
Psikiyatri Anabilim Dali
TR–23119 Elazig (Turkey)
Tel. +90 424 233 3555/2282 2300, Fax +90 424 238 8096, E-Mail kuloglum@yahoo.com

  

Article Information

Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 3, Number of References : 41

  

Publication Details

Neuropsychobiology (International Journal of Experimental and Clinical Research in Biological Psychiatry, Pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography)
Founded 1975 by J. Mendlewicz (Brussels)
Official Journal of the International Pharmaco-EEG Society (IPEG)

Vol. 46, No. 1, Year 2002 (Cover Date: Released August 2002)

Journal Editor: J. Mendlewicz, Brussels; B. Saletu, Vienna; P. Netter, Giessen; W.M. Herrmann, Berlin
ISSN: 0302–282X (print), 1423–0224 (Online)

For additional information: http://www.karger.com/journals/nps


Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Main Editor: J. Mendlewicz (Brussels) / Original Paper

Published online: 8/23/2002
Issue release date: August 2002

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


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