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Table of Contents
Vol. 39, No. 3, 2002
Issue release date: May–June 2002
Section title: Review
J Vasc Res 2002;39:191–207
(DOI:10.1159/000063685)

Superoxide in the Vascular System

Wolin M.S. · Gupte S.A. · Oeckler R.A.
Department of Physiology, New York Medical College, Valhalla, N.Y., USA

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Article / Publication Details

First-Page Preview
Abstract of Review

Received: 10/22/2001
Accepted: 12/17/2001
Published online: 8/22/2008
Issue release date: May–June 2002

Number of Print Pages: 17
Number of Figures: 2
Number of Tables: 2

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR

Abstract

Oxidant production and regulation is becoming increasingly important in the study of vascular signaling mechanisms, and recent reviews have characterized some of the possible roles for known downstream products of superoxide formation. In this review, we will examine current research in the field, with a special emphasis on the role of the superoxide molecule itself and its place amongst the slightly better understood roles of peroxide and peroxynitrite. The regulatory roles of oxidant species are wide-ranging, and their involvement in processes ranging from intracellular and receptor signaling mechanisms that regulate endothelial mediator release and vascular contractile function to processes that control cellular growth and apoptosis has been implied. Cellular sources of superoxide production and metabolism and the chemical interaction of oxidant species with specific components of cellular signaling mechanisms are considered important factors which determine physiological responses that control vascular function.

© 2002 S. Karger AG, Basel


  

Author Contacts

Dr. Michael S. Wolin
Department of Physiology
New York Medical College
Valhalla, NY 10595 (USA)
Tel. +1 914 594 4093, Fax +1 914 594 4826, E-Mail mike_wolin@nymc.edu

  

Article Information

Received: October 22, 2001
Accepted after revision: December 17, 2001
Published online: August 22, 2008
Number of Print Pages : 17
Number of Figures : 2, Number of Tables : 2, Number of References : 139

  

Publication Details

Journal of Vascular Research
Founded 1964 as Angiologica by M. Comèl and L. Laszt (1964–1973) continued as Blood Vessels by J.A. Bevan (1974–1991)

Vol. 39, No. 3, Year 2002 (Cover Date: May-June 2002)

Journal Editor: M.J. Mulvany, Aarhus
ISSN: 1018–1172 (Print), eISSN: 1423–0135 (Online)

For additional information: http://www.karger.com/journals/jvr


Article / Publication Details

First-Page Preview
Abstract of Review

Received: 10/22/2001
Accepted: 12/17/2001
Published online: 8/22/2008
Issue release date: May–June 2002

Number of Print Pages: 17
Number of Figures: 2
Number of Tables: 2

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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