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Vol. 23, No. 3, 2002
Issue release date: May–June 2002 (September 2002)
Section title: Research Article
Tumor Biol 2002;23:154–169
(DOI:10.1159/000064032)

The CA 125 Gene: A Newly Discovered Extension of the Glycosylated N-Terminal Domain Doubles the Size of This Extracellular Superstructure

O’Brien T.J. · Beard J.B. · Underwood L.J. · Shigemasa K.
aDepartment of Obstetrics and Gynecology, and bDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Ark., USA; cDepartment of Obstetrics and Gynecology, Hiroshima University School of Medicine, Hiroshima, Japan

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Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: 5/23/2002
Accepted: 6/24/2002
Published online: 9/5/2002

Number of Print Pages: 16
Number of Figures: 8
Number of Tables: 3

ISSN: 1010-4283 (Print)
eISSN: 1423-0380 (Online)

For additional information: http://www.karger.com/TBI

Abstract

CA 125 is a well-established marker for patients diagnosed with ovarian carcinoma. It is clearly elaborated in serous cystadenocarcinomas and less likely to be expressed in mucinous tumors. It has been 20 years since CA 125 was first recognized and it is only in recent years (the past 2) that some progress has been made toward cloning the gene, providing the basis for an understanding of the functional role of this molecule in embryonic development and neoplastic transformation. It is now clear that CA 125 is a large glycoprotein which is anchored to the epithelium by a transmembrane domain and is released into the extracellular space by enzymatic cleavage. Here, we describe a further major extension to the glycosylated extracellular amino terminal domain of this molecule. These additional data in association with our previous understanding of this molecule will provide the basis for our ability to understand the physiologic function of this molecule in biologic development and pathologic transformation.


  

Author Contacts

Timothy J. O’Brien
University of Arkansas for Medical Sciences
4301 West Markham, Slot 718
Little Rock, AR 72205 (USA)
Tel. +1 501 686 6696, Fax +1 501 686 8501, E-Mail tjobrien@uams.edu

  

Article Information

Received: Received: May 23, 2002
Accepted after revision: June 24, 2002
Number of Print Pages : 16
Number of Figures : 8, Number of Tables : 3, Number of References : 10

  

Publication Details

Tumor Biology (Tumor Markers and Translational Cancer Research)
Founded 1980 as ‘Oncodevelopmental Biology and Medicine’ by the ISOBM, continued 1984–1986 as ‘Tumour Biology’
The Journal of the International Society for Oncodevelopmental Biology and Medicine (ISOBM)

Vol. 23, No. 3, Year 2002 (Cover Date: May-June 2002 (Released September 2002))

Journal Editor: T. Stigbrand, Umeå; Managing Editor: P.D. Rye, Oslo
ISSN: 1010–4283 (print), 1423–0380 (Online)

For additional information: http://www.karger.com/journals/tbi


Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: 5/23/2002
Accepted: 6/24/2002
Published online: 9/5/2002

Number of Print Pages: 16
Number of Figures: 8
Number of Tables: 3

ISSN: 1010-4283 (Print)
eISSN: 1423-0380 (Online)

For additional information: http://www.karger.com/TBI


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