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Vol. 15, No. 5, 2002
Issue release date: September–October 2002
Section title: Paper
Skin Pharmacol Appl Skin Physiol 2002;15:282–290
(DOI:10.1159/000064531)

Antioxidants and the Response of Skin to Oxidative Stress: Vitamin E as a Key Indicator

Packer L.a · Valacchi G.b
aUniversity of Southern California, Molecular Pharmacology and Toxicology School of Pharmacy, Los Angeles, Calif., bCenter for Comparative Respiratory Biology and Medicine, Department of Internal Medicine, University of California, Davis, Calif., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 9/16/2002
Issue release date: September–October 2002

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 1

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

As the outermost barrier of the body, the skin is directly and frequently exposed to a prooxidative environment, including solar UVA and UVB radiation, and air pollution. The skin is equipped with an elaborate system of antioxidant substances and enzymes that includes a network of redox active antioxidants. Among these, vitamin E has been identified as the predominant antioxidant both in murine and human skin and shows a characteristic gradient with lower levels towards the outer stratum corneum layers. Skin exposure to UV and ozon alone and in combination resulted in a significant potentiation of the UV-induced vitamin E depletion. Oxidants and antioxidants play an important role in maintaining a balance between free radicals produced by metabolism or derived from environmental sources. Cellular antioxidants may change their redox state, be targeted for destruction, regulate oxidative process involved in signal transduction, affect gene expression and pathways of cell proliferation and death. Here we provide an overview of the antioxidant system with a special relevance to skin.

© 2002 S. Karger AG, Basel


  

Author Contacts

Lester Packer
University of Southern California
Molecular Pharmacology and Toxicology School of Pharmacy
Los Angeles, CA 90089-9621 (USA), Tel. +1 510 865 5461
Fax +1 323 224 7473, E-Mail packerresearch@aol.com

  

Article Information

Number of Print Pages : 9
Number of Figures : 4, Number of Tables : 1, Number of References : 56

  

Publication Details

Skin Pharmacology and Applied Skin Physiology (Journal of Pharmacological and Biophysical Research)
Incorporating ‘Bioengineering and the Skin’; Founded in 1988 by H. Schaefer
Official Journal of the Skin Pharmacology Society (SPS)

Vol. 15, No. 5, Year 2002 (Cover Date: September-October 2002)

Journal Editor: Hans F. Merk, Aachen
ISSN: 1422–2868 (print), 1422–2906 (Online)

For additional information: http://www.karger.com/journals/sph


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 9/16/2002
Issue release date: September–October 2002

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 1

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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