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Table of Contents
Vol. 58, No. 2, 2002
Issue release date: 2002
Section title: Original Paper
Horm Res 2002;58:83–87
(DOI:10.1159/000064658)

Normal Progression of Testicular Size in Boys with Idiopathic Short Stature and Isolated Growth Hormone Deficiency Treated with Growth Hormone: Experience from the KIGS

Lindgren A.C.a · Chatelain P.b · Lindberg A.a · Price D.A.c · Ranke M.B.d · Reiter E.O.e · Wilton P.a
aPharmacia, Stockholm, Sweden; bUniversity Claude-Bernard, Lyon, France; cSt. Mary’s Hospital, Manchester, UK; dUniversity Children’s Hospital, Tübingen, Germany; eBaystate Medical Center, Springfield, Mass., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 05, 2001
Accepted: April 19, 2002
Published online: August 23, 2002
Issue release date: 2002

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

Background: The aim of this retrospective analysis was to evaluate the effects of growth hormone (GH) treatment on testicular development in boys with idiopathic short stature (ISS) and isolated GH deficiency (IGHD) followed in the KIGS (Pharmacia International Growth Database). Methods: For inclusion in the study, the patients had to have received more than 1 year of prepubertal GH treatment, at least 4 consecutive years of GH treatment in total, and to have attained their final height, defined as a height velocity of less than 2 cm/year. Data on 107 boys in the KIGS database have been analyzed. Results: No significant differences in duration of GH treatment and testicular volume at the start of treatment or at final height were found between the boys with ISS and those with IGHD. The progression of testicular volume in boys with ISS or IGHD during GH treatment did not differ from the reference population. Conclusions: This analysis shows that GH treatment does not alter testicular growth in boys with ISS or IGHD. However, prospective controlled studies are needed to rule out moderate attenuating or stimulating effects.

© 2002 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 05, 2001
Accepted: April 19, 2002
Published online: August 23, 2002
Issue release date: 2002

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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