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Vol. 48, No. 3, 2002
Issue release date: July 2002
Section title: Experimental Chemotherapy
Chemotherapy 2002;48:144–147
(DOI:10.1159/000064920)

Antiviral Activity of Petiveria alliacea against the Bovine Viral Diarrhea Virus

Ruffa M.J. · Perusina M. · Alfonso V. · Wagner M.L. · Suriano M. · Vicente C. · Campos R. · Cavallaro L.
aCátedra de Virología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, bMuseo de Farmacobotánica ‘Juan A. Dominguez’, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina

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Article / Publication Details

First-Page Preview
Abstract of Experimental Chemotherapy

Published online: 7/15/2002

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 3

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: http://www.karger.com/CHE

Abstract

Background: Natural products are a relevant source of antiviral drugs. Five medicinal plants used in Argentina have been assayed to detect inhibition of viral growth. Methods: Antiviral activity of the infusions and methanolic extracts of Aristolochia macroura, Celtis spinosa, Plantago major, Schinus areira, Petiveria alliacea and four extracts obtained from the leaves and stems of the last plant were evaluated by the plaque assay. Results:P. alliacea, unlike A. macroura, C. spinosa, P. major and S. areira, inhibited bovine viral diarrhea virus (BVDV) replication. Neither P. alliacea nor the assays of the other plants were active against herpes simplex virus type 1, poliovirus type 1, adenovirus serotype 7 and vesicular stomatitis virus type 1. Four extracts of P. alliacea were assayed to detect anti-BVDV activity. Ethyl acetate (EC50 of 25 µg/ml) and dichloromethane (EC50 of 43 µg/ml) extracts were active; moreover, promising SI (IC50/EC50) values were obtained. Conclusion: BVDV is highly prevalent in the cattle population, there are no antiviral compounds available; additionally, it is a viral model of the hepatitis C virus. For these reasons and in view of the results obtained, the isolation and characterization of the antiviral components present in the P. alliacea extracts is worth carrying out in the future.


  

Author Contacts

L. Cavallaro
Facultad de Farmacia y Bioquímica, Cátedra de Virología
Junín 956, 4° piso, Buenos Aires 1113 (Argentina)
Tel. +54 1149648264, Fax +54 1145083645
E-Mail lcavalla@ffyb.uba.ar

  

Article Information

Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 3, Number of References : 18

  

Publication Details

Chemotherapy (International Journal of Experimental and Clinical Chemotherapy)
Founded 1959 as ‘Chemotherapia’

Vol. 48, No. 3, Year 2002 (Cover Date: July 2002)

Journal Editor: H. Schönfeld, Grenzach-Wyhlen
ISSN: 0009–3157 (print), 1421–9794 (Online)

For additional information:http://www.karger.com/journals/che


Article / Publication Details

First-Page Preview
Abstract of Experimental Chemotherapy

Published online: 7/15/2002

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 3

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: http://www.karger.com/CHE


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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