Multiple Actions of Pituitary Adenylyl Cyclase Activating Peptide in Nervous System Development and RegenerationWaschek J.A.
Department of Psychiatry and Mental Retardation Research Center, University of California at Los Angeles, Neuropsychiatric Institute, Los Angeles, Calif., USA
Pituitary adenylyl cyclase activating peptide (PACAP) is widely expressed in the embryonic brain at the onset of neurogenesis, and is strongly upregulated in several models of nerve injury. Moreover, high-affinity PACAP receptors are expressed in proliferative zones in the embryonic and postnatal nervous system suggesting that PACAP regulates the development of both neuronal and glial precursors. Tissue culture studies indicate that PACAP exerts a variety of growth factor-like actions that depend on the origin of the cell population and developmental stage. These effects include regulation of proliferation, survival, maturation, neurite outgrowth, and expression of trophic factors, cytokines and trk receptors. The presence of other growth factors can also markedly affect these actions of PACAP, for example, reversing PACAP’s effect from proliferative to antiproliferative. In vivo models now provide additional evidence that PACAP acts in neural development and regeneration.
© 2002 S. Karger AG, Basel
James A. Waschek, PhD
68-225 N.P.I., University of California at Los Angeles
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Received: December 19, 2001
Accepted: January 1, 2002
Number of Print Pages : 10
Number of Figures : 1, Number of Tables : 3, Number of References : 76
Vol. 24, No. 1, Year 2002 (Cover Date: January-February (Released July 2002))
Journal Editor: A.T. Campagnoni, Los Angeles, Calif.
ISSN: 0378–5866 (print), 1421–9859 (Online)
For additional information: http://www.karger.com/journals/dne