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Vol. 24, No. 1, 2002
Issue release date: January–February (July 2002)
Section title: Review
Dev Neurosci 2002;24:14–23
(DOI:10.1159/000064942)

Multiple Actions of Pituitary Adenylyl Cyclase Activating Peptide in Nervous System Development and Regeneration

Waschek J.A.
Department of Psychiatry and Mental Retardation Research Center, University of California at Los Angeles, Neuropsychiatric Institute, Los Angeles, Calif., USA

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Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 7/19/2002
Issue release date: January–February (July 2002)

Number of Print Pages: 10
Number of Figures: 1
Number of Tables: 3

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE

Abstract

Pituitary adenylyl cyclase activating peptide (PACAP) is widely expressed in the embryonic brain at the onset of neurogenesis, and is strongly upregulated in several models of nerve injury. Moreover, high-affinity PACAP receptors are expressed in proliferative zones in the embryonic and postnatal nervous system suggesting that PACAP regulates the development of both neuronal and glial precursors. Tissue culture studies indicate that PACAP exerts a variety of growth factor-like actions that depend on the origin of the cell population and developmental stage. These effects include regulation of proliferation, survival, maturation, neurite outgrowth, and expression of trophic factors, cytokines and trk receptors. The presence of other growth factors can also markedly affect these actions of PACAP, for example, reversing PACAP’s effect from proliferative to antiproliferative. In vivo models now provide additional evidence that PACAP acts in neural development and regeneration.

© 2002 S. Karger AG, Basel


  

Author Contacts

James A. Waschek, PhD
68-225 N.P.I., University of California at Los Angeles
760 Westwood Plaza
Los Angeles, CA 90024 (USA)
Tel. +1 310 825 0179, Fax +1 310 206 5061, E-Mail jwaschek@mednet.ucla.edu

  

Article Information

Received: December 19, 2001
Accepted: January 1, 2002
Number of Print Pages : 10
Number of Figures : 1, Number of Tables : 3, Number of References : 76

  

Publication Details

Developmental Neuroscience

Vol. 24, No. 1, Year 2002 (Cover Date: January-February (Released July 2002))

Journal Editor: A.T. Campagnoni, Los Angeles, Calif.
ISSN: 0378–5866 (print), 1421–9859 (Online)

For additional information: http://www.karger.com/journals/dne


Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 7/19/2002
Issue release date: January–February (July 2002)

Number of Print Pages: 10
Number of Figures: 1
Number of Tables: 3

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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