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Vol. 9, No. 4, 2002
Issue release date: July–August 2002
Section title: Review
J Biomed Sci 2002;9:292–298
(DOI:10.1159/000064998)

Damaged DNA and Miscounted Chromosomes: Human T Cell Leukemia Virus Type I Tax Oncoprotein and Genetic Lesions in Transformed Cells

Marriott S.J.a,b · Lemoine F.J.b · Jeang K.T.c
aDepartment of Molecular Virology and Microbiology, bProgram in Cell and Molecular Biology, Baylor College of Medicine, Houston, Tex., cLaboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Md., USA

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Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 7/19/2002
Issue release date: July–August 2002

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 0

ISSN: 1021-7770 (Print)
eISSN: 1423-0127 (Online)

For additional information: http://www.karger.com/JBS

Abstract

Genetic instability is a recurring theme in human cancers. Although the molecular mechanisms mediating this effect commonly observed in transformed cells are not completely understood, it has been proposed to involve either the loss of DNA repair capabilities or the loss of chromosomal stability. The transforming retrovirus human T cell leukemia virus type I (HTLV-I) encodes a viral oncoprotein Tax, which is believed to cause the genomic instability characteristic of HTLV-I-infected cells. This review focuses on the ability of HTLV-I Tax to disrupt the cellular processes of DNA repair and chromosomal segregation. The consequences of these effects as well as the evolutionary advantage this may provide to HTLV-I are discussed.

© 2002 National Science Council, ROC and S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 7/19/2002
Issue release date: July–August 2002

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 0

ISSN: 1021-7770 (Print)
eISSN: 1423-0127 (Online)

For additional information: http://www.karger.com/JBS


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