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Table of Contents
Vol. 129, No. 1, 2002
Issue release date: September 2002
Section title: Review
Int Arch Allergy Immunol 2002;129:1–18
(DOI:10.1159/000065179)

Characterization and Immunobiology of House Dust Mite Allergens

Thomas W.R.a · Smith W.-A.a · Hales B.J.a · Mills K.L.a · O’Brien R.M.b
aCentre for Child Health Research, University of Western Australia, Telethon Institute for Child Health Research, West Perth, W.A. and bDepartment of Medicine, University of Melbourne, Western General Hospital, Footscray, Vic., Australia

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Article / Publication Details

First-Page Preview
Abstract of Review

Received: July 18, 2002
Published online: September 30, 2002
Issue release date: September 2002

Number of Print Pages: 18
Number of Figures: 0
Number of Tables: 2

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

The examination of house dust mite extracts has indicated that over 30 different proteins can induce IgE antibody in patients allergic to the house dust mite. There are however dominant specificities especially the group 1 and 2 allergens which can account for much of the allergenicity of extracts. Of the 19 denominated allergens, the major IgE binding has been reported for the group 1, 2, 3, 9, 11, 14 and 15 allergens. The high-molecular-weight group 11, 14 and 15 allergens have only recently been described and although high IgE binding has been anticipated from immunoblotting, there is a need for considerable corroboration. Similarly, the study of the group 3 and 9 serine protease allergens has been incomplete. The group 4, 5, 7 and 8 allergens have shown intermediate IgE binding and the group 10 tropomyosins are of interest because of their potential cross-reactivity with allergen from disparate species. Although the progress with the production of recombinant group 1 allergens has been recent, many of the allergens can be produced as high IgE-binding polypeptides. The tertiary structure of the group 2 allergens has been determined from recombinant proteins and they are an excellent model for the investigation of modified allergens. An unexpected property of the group 1, 2 and 3 allergens has been the high degree of polymorphism found by cDNA analysis. It has however been possible to identify sequences to represent the variation in the natural allergens. The group 7 and 14 allergens show secondary modifications which vary in different extracts creating batch variation. While some estimate of the importance of allergens can be obtained from IgE binding, few analyses of T-cell responses have been made and these regulate both the development of, and the protection from sensitization.

© 2002 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Review

Received: July 18, 2002
Published online: September 30, 2002
Issue release date: September 2002

Number of Print Pages: 18
Number of Figures: 0
Number of Tables: 2

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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