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Minireview

Unexpected Renal Actions of Erythropoietin

Westenfelder C.

Author affiliations

Division of Nephrology (111 N), VA and University of Utah Medical Centers, Salt Lake City, Utah, USA

Related Articles for ""

Exp Nephrol 2002;10:294–298

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Article / Publication Details

First-Page Preview
Abstract of Minireview

Received: November 07, 2001
Accepted: January 04, 2002
Published online: October 09, 2002
Issue release date: 2002

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 0


eISSN: 1660-2129 (Online)

For additional information: http://www.karger.com/NEE

Abstract

Erythropoietin (EPO) in the renal cortex is synthesized by fibroblast-like cells that are in direct contact with capillaries and adjacent tubular cells. Prompted by this anatomical relationship, we asked whether renal cells express EPO receptors (EPORs) through which EPO could act as a renotropic cytokine. We found that all regions of human, rat and mouse kidney, mesangial and proximal and distal tubular cells express authentic EPORs. Similar EPOR expression was detected in kidney cancer cells, and in cyst epithelia from polycystic kidneys. In vitro, EPO stimulated mitogenesis in all normal and malignant cells, and cell survival and motogenesis in injured tubular cells. Since the normal kidney is essentially unresponsive to EPO, we hypothesized that EPO’s cytokine effects in the kidney are revealed when tubular cells are induced to proliferate by a prior insult, as occurs in acute renal failure. Accordingly, we found that EPO treatment of rats with ‘ischemic’ acute renal failure afforded renoprotection and accelerated functional recovery.

© 2002 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Minireview

Received: November 07, 2001
Accepted: January 04, 2002
Published online: October 09, 2002
Issue release date: 2002

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 0


eISSN: 1660-2129 (Online)

For additional information: http://www.karger.com/NEE


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