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Vol. 46, No. 2, 2002
Issue release date: October 2002
Section title: Biological Psychiatry. Main Editor: J. Mendlewicz (Brussels) / Original Paper
Neuropsychobiology 2002;46:76–84
(DOI:10.1159/000065416)

Innate Immunity Associated with Inflammatory Responses and Cytokine Production against Common Dietary Proteins in Patients with Autism Spectrum Disorder

Jyonouchi H. · Sun S. · Itokazu N.
Department of Pediatrics, University of Minnesota, Minneapolis, Minn., USA

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Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Main Editor: J. Mendlewicz (Brussels) / Original Paper

Published online: 10/7/2002

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 4

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

Objectives: Children with autism spectrum disorder (ASD) frequently reveal various gastrointestinal (GI) symptoms that may resolve with an elimination diet along with apparent improvement of some of the behavioral symptoms. Evidence suggests that ASD may be accompanied by aberrant (inflammatory) innate immune responses. This may predispose ASD children to sensitization to common dietary proteins (DP), leading to GI inflammation and aggravation of some behavioral symptoms. Methods: We measured IFN-γ, IL-5, and TNF-α production against representative DPs [gliadin, cow’s milk protein (CMP), and soy] by peripheral blood mononuclear cells (PBMCs) from ASD and control children [those with DP intolerance (DPI), ASD siblings, and healthy unrelated children]. We evaluated the results in association with proinflammatory and counter-regulatory cytokine production with endotoxin (LPS), a microbial product of intestinal flora and a surrogate stimulant for innate immune responses. Results: ASD PBMCs produced elevated IFN-γ and TNF-α, but not IL-5 with common DPs at high frequency as observed in DPI PBMCs. ASD PBMCs revealed increased proinflammatory cytokine responses with LPS at high frequency with positive correlation between proinflammatory cytokine production with LPS and IFN-γ and TNF-α production against DPs. Such correlation was less evident in DPI PBMCs. Conclusion: Immune reactivity to DPs may be associated with apparent DPI and GI inflammation in ASD children that may be partly associated with aberrant innate immune response against endotoxin, a product of the gut bacteria.


  

Author Contacts

Harumi Jyonouchi, MD
Division of Allergy/Immunology/Pulmonology/ID
Department of Pediatrics, University of Medicine and Dentistry of New Jersey
185 South Orange Ave., University Heights, Newark, NJ 07103-2714 (USA)
Tel. +1 973 972 5066, Fax +1 973 972 6443

  

Article Information

Number of Print Pages : 9
Number of Figures : 3, Number of Tables : 4, Number of References : 30

  

Publication Details

Neuropsychobiology (International Journal of Experimental and Clinical Research in Biological Psychiatry, Pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography)
Founded 1975 by J. Mendlewicz (Brussels)
Official Journal of the International Pharmaco-EEG Society (IPEG)

Vol. 46, No. 2, Year 2002 (Cover Date: Released October 2002)

Journal Editor: J. Mendlewicz, Brussels; B. Saletu, Vienna; P. Netter, Giessen; W.M. Herrmann, Berlin
ISSN: 0302–282X (print), 1423–0224 (Online)

For additional information: http://www.karger.com/journals/nps


Article / Publication Details

First-Page Preview
Abstract of Biological Psychiatry. Main Editor: J. Mendlewicz (Brussels) / Original Paper

Published online: 10/7/2002

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 4

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


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