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Table of Contents
Vol. 48, No. 6, 2002
Issue release date: November – December
Section title: Clinical Section
Gerontology 2002;48:392–400
(DOI:10.1159/000065502)

Late-Life Depression: Rationalizing Pharmacological Treatment Options

Montgomery S.A.
Imperial College School of Medicine, London, UK

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Article / Publication Details

First-Page Preview
Abstract of Clinical Section

Received: October 18, 2001
Accepted: November 30, 2001
Published online: October 18, 2002
Issue release date: November – December

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 2

ISSN: 0304-324X (Print)
eISSN: 1423-0003 (Online)

For additional information: http://www.karger.com/GER

Abstract

Background: Depressive symptoms in late life are a major concern as they increase disability and aggravate existing medical conditions. Depression is underrecognised and undertreated in the elderly, be it due to somatic symptoms, comorbid physical illness or anxiety, or because it is accepted as a normal feature of ageing. There is little doubt that effective and well-tolerated antidepressant therapy is required. Objective: This paper reviews the antidepressant treatment options for late-life depression (selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, mixed noradrenergic and serotonergic agents), in terms of their efficacy, safety and pharmacokinetics in elderly patients. Results: In addition to proven efficacy, selection of an antidepressant agent for late-life depression must be based on an understanding of safety and pharmacokinetic issues associated with each agent. Comorbid conditions and lifestyle characteristics of the elderly that are different to those encountered in the younger adult population should also be considered. Conclusion: To date, published clinical evidence in the elderly suggests that the first-choice agents for treating late-life depression are the SSRIs.

© 2002 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Clinical Section

Received: October 18, 2001
Accepted: November 30, 2001
Published online: October 18, 2002
Issue release date: November – December

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 2

ISSN: 0304-324X (Print)
eISSN: 1423-0003 (Online)

For additional information: http://www.karger.com/GER


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.