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Vol. 39, No. 4, 2002
Issue release date: July–August 2002
Section title: Research Paper
J Vasc Res 2002;39:311–319
(DOI:10.1159/000065543)

Vascular Function in Women with Previous Gestational Diabetes mellitus

Hannemann M.M. · Liddell W.G. · Shore A.C. · Clark P.M. · Tooke J.E.
aInstitute of Biomedical Research, Peninsula Medical School, Exeter, and bRegional Endocrine Laboratory, University Hospital, Birmingham NHS Trust, Birmingham, UK

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Article / Publication Details

First-Page Preview
Abstract of Research Paper

Published online: 8/12/2002
Issue release date: July–August 2002

Number of Print Pages: 9
Number of Figures: 6
Number of Tables: 1

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR

Abstract

It is hypothesised that vascular dysfunction, which characterises type 2 diabetes, may predate development of hyperglycaemia. 17 women with previous gestational diabetes mellitus, and thus at risk of developing type 2 diabetes, were matched with normal controls for body mass index, menstrual phase, smoking, age, blood pressure, and lipid profiles. All had normal glucose tolerance. Tests of microvascular and macrovascular function, including endothelium-dependent and -independent vasodilatation, were performed. Laser Doppler fluximetry of maximum skin microvascular hyperaemia in response to local heating of the dorsum of the foot to 42°C for 30 min was impaired in subjects compared to controls [subjects = 1.15 (0.73–1.73) V median (range) versus controls = 1.50 (0.95–2.29) V, p = 0.008]. There were no differences in laser Doppler perfusion imaging of responses to forearm skin iontophoresis of acetylcholine [subjects = 1.59 (0.32–2.55) V median (range) versus controls = 1.79 (0.72–2.06) V; p = 0.81] and sodium nitroprusside [subjects = 1.39 (0.8–3.14) V versus controls = 1.41 (0.34–2.19) V; p = 0.68], ultrasound estimation of brachial artery flow-mediated dilatation [subjects = 1.65 (–0.5–9.07)% versus controls = 2.77 (0.63–6.6)%; p = 0.42] and glyceryl trinitrate-induced dilatation [subjects = 15.20 (6.64–20.91)% versus controls = 15.92 (3.94–22.09)%; p = 0.48]. Microvascular maximum hyperaemia was impaired in the index group, suggesting the presence of a defect in vascular function. This defect was not explained by those aspects of endothelial function measured by the other techniques.


  

Author Contacts

Dr. M.M. Hannemann
Centre for Clinical Microvascular Research, Institute of Biomedical Research
Peninsula Medical School
Barrack Road, Exeter, EX2 5AX (UK)
Tel. +44 1392 403081, Fax +44 1392 403027, E-Mail M.M.Hannemann@exeter.ac.uk

  

Article Information

Received: Received: May 28, 2001
Accepted after revision: January 25, 2002
Number of Print Pages : 9
Number of Figures : 6, Number of Tables : 1, Number of References : 55

  

Publication Details

Journal of Vascular Research
Founded 1964 as Angiologica by M. Comèl and L. Laszt (1964–1973) continued as Blood Vessels by J.A. Bevan (1974–1991)

Vol. 39, No. 4, Year 2002 (Cover Date: July-August 2002)

Journal Editor: M.J. Mulvany, Aarhus
ISSN: 1018–1172 (print), 1423–0135 (Online)

For additional information: http://www.karger.com/journals/jvr


Article / Publication Details

First-Page Preview
Abstract of Research Paper

Published online: 8/12/2002
Issue release date: July–August 2002

Number of Print Pages: 9
Number of Figures: 6
Number of Tables: 1

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR


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