Roles of Hematopoietic Transcription Factors GATA-1 and GATA-2 in the Development of Red Blood Cell LineageOhneda K. · Yamamoto M.
Center for Tsukuba Advanced Research Alliance and Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan
The transcription factors GATA-1 and GATA-2 play key roles in gene regulation during erythropoiesis. Gene ablation studies in mouse revealed that GATA-2 is crucial for the maintenance and proliferation of immature hematopoietic progenitors, whereas GATA-1 is essential for the survival of erythroid progenitors as well as the terminal differentiation of erythroid cells. Both GATA-1 and GATA-2 are regulated in a cell-type-specific manner, their expression being strictly controlled during the development and differentiation of erythroid cells. Closer examination revealed a cross-regulatory mechanism by which GATA-1 can control the expression of GATA-2 and vice versa, possibly via essential GATA binding sites in their cis-acting elements. In addition, recent studies identified several human inherited hematopoietic disorders that are caused by mutations in cis-acting GATA binding motifs or mutations in GATA-1 itself.
Masayuki Yamamoto, MD
Center for TARA, University of Tsukuba
1-1-1 Tennoudai, Tsukuba 305-8577 (Japan)
Tel. +81 298 53 6158, Fax +81 298 53 7318
Number of Figures : 2, Number of Tables : 2, Number of References : 35
Affiliated with Molecular Biology of Hematopoiesis Symposium
Vol. 108, No. 4, Year 2002 (Cover Date: Released November 2002)
Journal Editor: I. Ben-Bassat, Tel Hashomer
ISSN: 0001–5792 (print), 1421–9662 (Online)
For additional information: http://www.karger.com/journals/aha