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Vol. 108, No. 4, 2002
Issue release date: November 2002
Section title: Current Topics in Molecular Basis of Red Cell Disorders. Guest Editor: Kanno, H. (Tokyo)
Acta Haematol 2002;108:237–245
(DOI:10.1159/000065660)

Roles of Hematopoietic Transcription Factors GATA-1 and GATA-2 in the Development of Red Blood Cell Lineage

Ohneda K. · Yamamoto M.
Center for Tsukuba Advanced Research Alliance and Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan

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Article / Publication Details

First-Page Preview
Abstract of Current Topics in Molecular Basis of Red Cell Disorders. Guest Editor: Kanno, H. (Tokyo)

Published online: 11/21/2002
Issue release date: November 2002

Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 2

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA

Abstract

The transcription factors GATA-1 and GATA-2 play key roles in gene regulation during erythropoiesis. Gene ablation studies in mouse revealed that GATA-2 is crucial for the maintenance and proliferation of immature hematopoietic progenitors, whereas GATA-1 is essential for the survival of erythroid progenitors as well as the terminal differentiation of erythroid cells. Both GATA-1 and GATA-2 are regulated in a cell-type-specific manner, their expression being strictly controlled during the development and differentiation of erythroid cells. Closer examination revealed a cross-regulatory mechanism by which GATA-1 can control the expression of GATA-2 and vice versa, possibly via essential GATA binding sites in their cis-acting elements. In addition, recent studies identified several human inherited hematopoietic disorders that are caused by mutations in cis-acting GATA binding motifs or mutations in GATA-1 itself.


  

Author Contacts

Masayuki Yamamoto, MD
Center for TARA, University of Tsukuba
1-1-1 Tennoudai, Tsukuba 305-8577 (Japan)
Tel. +81 298 53 6158, Fax +81 298 53 7318
E-Mail masi@tara.tsukuba.ac.jp

  

Article Information

Number of Figures : 2, Number of Tables : 2, Number of References : 35

  

Publication Details

Acta Haematologica
Founded 1948
Affiliated with Molecular Biology of Hematopoiesis Symposium

Vol. 108, No. 4, Year 2002 (Cover Date: Released November 2002)

Journal Editor: I. Ben-Bassat, Tel Hashomer
ISSN: 0001–5792 (print), 1421–9662 (Online)

For additional information: http://www.karger.com/journals/aha


Article / Publication Details

First-Page Preview
Abstract of Current Topics in Molecular Basis of Red Cell Disorders. Guest Editor: Kanno, H. (Tokyo)

Published online: 11/21/2002
Issue release date: November 2002

Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 2

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


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