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Vol. 129, No. 2, 2002
Issue release date: October 2002
Section title: Review
Int Arch Allergy Immunol 2002;129:108–112
(DOI:10.1159/000065884)

Petasins in the Treatment of Allergic Diseases: Results of Preclinical and Clinical Studies

Thomet O.A.R. · Simon H.-U.
aDepartment of Pharmacology, University of Bern, and bDepartment of Medicine, GlaxoSmithKline, Münchenbuchsee, Switzerland

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Article / Publication Details

First-Page Preview
Abstract of Review

Received: 8/15/2002
Published online: 10/28/2002

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Plant extracts are causing an increased interest in the treatment of many chronic diseases, including asthma and other allergic diseases. Several laboratories characterized petasins (petasin, isopetasin, and neopetasin) isolated from extracts of butterbur (Petasites hybridus) as pharmacologically active components, which inhibit leukotriene synthesis in leukocytes. The molecular mechanisms by which petasins abrogate inflammatory effector cell functions have, at least partially, been identified. In vitro studies revealed that petasins may have several intracellular targets and this may depend on the stereoisomer used. In an open clinical trial in patients suffering from allergic rhinitis, a reduction of leukotriene and histamine levels in nasal fluids was associated with the butterbur extract administration. To better evaluate the clinical value in this particular allergic disease, the clinical efficacy of the drug was compared with an established antihistamine treatment scheme in a double-blind study; no significant difference was observed between the two treatment groups. In this article, we critically review recently published work and summarize the current stage in the pharmacological characterization of butterbur extracts.


  

Author Contacts

Correspondence to: Dr. Hans-Uwe Simon
Department of Pharmacology, University of Bern
Friedbühlstrasse 49
CH–3010 Bern (Switzerland)
Tel. +41 31 632 3281, Fax +41 31 632 4992, E-Mail hus@pki.unibe.ch

  

Article Information

Number of Figures : 1, Number of Tables : 0, Number of References : 46

  

Publication Details

International Archives of Allergy and Immunology
Founded 1950

Vol. 129, No. 2, Year 2002 (Cover Date: October 2002)

Journal Editor: D. Kraft, Vienna
ISSN: 1018–2438 (print), 1423–0097 (Online)

For additional information:http://www.karger.com/journals/iaa


Article / Publication Details

First-Page Preview
Abstract of Review

Received: 8/15/2002
Published online: 10/28/2002

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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