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Vol. 82, No. 4, 2002
Issue release date: October 2002
Section title: Original Paper
Biol Neonate 2002;82:222–227
(DOI:10.1159/000065890)

Hypothermia Reduces Neurological Damage in Asphyxiated Newborn Infants

Compagnoni G. · Pogliani L. · Lista G. · Castoldi F. · Fontana P. · Mosca F.
Department of Neonatology, ICP, NICU-‘V. Buzzi’ Children’s Hospital, Milan, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 6/13/2002
Published online: 10/16/2002

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 4

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO

Abstract

Background: Perinatal asphyxia remains one of the most devastating neurologic processes. There is experimental and clinical evidence that cerebral cooling may suppress the biochemical cascades leading to delayed cerebral damage. Objective: To determine if hypothermia started soon after delivery reduces cerebral damage in term infants. Design/Methods: Retrospective chart analysis with historical controls. Ten asphyxiated newborns treated with hypothermia between October 1998 and October 1999 were compared to 11 asphyxiated newborns admitted from September 1997 to September 1998. Characteristics at birth of infants of the two groups (control and hypothermia) were comparable. After obtaining parental consent, whole-body hypothermia was induced before the 6th hour of life by placing a cold blanket (Polar Air, Augustine Medical Inc., model 600) around the body of the patients. Rectal temperature was maintained between 32 and 34°C for 72 h. Outcome was assessed by neurological evaluation at birth and every 3 months up to the 12th month. Brain MRI was performed in the 2nd month. We had no evidence of severe adverse events related to hypothermia. In the hypothermic group there was a significant (p < 0.05) reduction of major neurologic abnormalities at follow-up and abnormal MRI findings. Conclusions: Hypothermia appears to be safe. Our results on morphological damage evaluated by brain MRI and neurological outcome are encouraging: randomized controlled trials are needed to confirm this experience.


  

Author Contacts

G. Compagnoni, MD
Department of Neonatology
NICU-‘V. Buzzi’ Children’s Hospital
Via Castelvetro, 32, I–20154 Milan (Italy)
Tel. +39 02 57995341, Fax +39 02 57995342, E-Mail intensivist@tiscalinet.it

  

Article Information

Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 4, Number of References : 38

  

Publication Details

Biology of the Neonate (Foetal and Neonatal Research)

Vol. 82, No. 4, Year 2002 (Cover Date: Released October 2002)

Journal Editor: J.P. Relier, Paris
ISSN: 0006–3126 (print), 1421–9727 (Online)

For additional information: http://www.karger.com/journals/bon


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 6/13/2002
Published online: 10/16/2002

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 4

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


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