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Vol. 76, No. 4, 2002
Issue release date: October 2002
Section title: Central Effects of Estrogens and Reproductive Neuroendocrinology
Neuroendocrinology 2002;76:214–222
(DOI:10.1159/000065951)

Estrogenic Properties of Raloxifene, but Not Tamoxifen, on D2 and D3 Dopamine Receptors in the Rat Forebrain

Landry M. · Lévesque D. · Di Paolo T.
aMolecular Endocrinology and Oncology Research Center and Faculté de Pharmacie, bUnité de Neuroscience, Centre de Recherche du CHUQ and Département de Médecine, Faculté de Médecine, Université Laval, Sainte-Foy, Que., Canada

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Article / Publication Details

First-Page Preview
Abstract of Central Effects of Estrogens and Reproductive Neuroendocrinology

Accepted: 1/29/2002
Published online: 10/31/2002

Number of Print Pages: 9
Number of Figures: 5
Number of Tables: 1

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN

Abstract

The present study investigated the estrogenic specificity of the modulation of dopamine D2 and D3 receptors by comparing the effects of estradiol with tamoxifen or raloxifene. These compounds have estrogenic and/or antiestrogenic activity depending on the target tissue. Two weeks after ovariectomy of female rats, we observed a 60% decrease in the uterine weight, which was prevented by a replacement therapy of 2 weeks with 17β-estradiol. A tamoxifen or raloxifene treatment of 2 weeks increased uterine weights by 35 and 15%, respectively, but significantly less than estradiol treatment. Ovariectomy decreased dopamine D2 receptor specific binding (20%) in the dorsolateral part of the anterior striatum and these receptors were left unchanged in the other parts of the striatum as well as in the olfactory tubercle and the nucleus accumbens. 17β-Estradiol and raloxifene, but not tamoxifen treatment prevented this decrease. Ovariectomy left dopamine D3 receptor specific binding unchanged. However, estradiol and raloxifene treatment decreased dopamine D3 receptor binding in the islands of Calleja, the core and shell of the nucleus accumbens and the dorsal part of the anterior striatum, compared with ovariectomized rats. Our results show that raloxifene, but not tamoxifen, has an agonist estrogenic activity on dopamine receptors. Furthermore, estradiol and raloxifene have opposite effects on specific binding to dopamine D2 and D3 receptors.


  

Author Contacts

Thérèse Di Paolo
Molecular Endocrinology and Oncology Research Center
Laval University Medical Center (CHUL)
2705, Laurier Boulevard, Sainte-Foy, Que., G1V 4G2 (Canada)
Tel. +1 418 654 2296, Fax +1 418 654 2761, E-Mail therese.dipaolo@crchul.ulaval.ca

  

Article Information

Received: Received: January 29, 2002
Accepted after revision: August 1, 2002
Number of Figures : 5, Number of Tables : 1, Number of References : 42

  

Publication Details

Neuroendocrinology (International Journal for Basic and Clinical Studies on Neuroendocrine Relationships)
Founded 1965 by E. Bajusz. Continued by K.M. Knigge (1973–1978), W.F. Ganong (1979–1984), S.M. McCann (1985–1993)

Vol. 76, No. 4, Year 2002 (Cover Date: October 2002)

Journal Editor: C. Kordon, Paris
ISSN: 0028–3835 (print), 1423–0194 (Online)

For additional information: http://www.karger.com/journals/nen


Article / Publication Details

First-Page Preview
Abstract of Central Effects of Estrogens and Reproductive Neuroendocrinology

Accepted: 1/29/2002
Published online: 10/31/2002

Number of Print Pages: 9
Number of Figures: 5
Number of Tables: 1

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN


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