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Vol. 12, No. 5, 1999
Issue release date: September–October 1999
Section title: Original Research Article
Skin Pharmacol Appl Skin Physiol 1999;12:235–246
(DOI:10.1159/000066248)

The Effect of Liposomes on Skin Barrier Structure

Coderch L.a · de Pera M.a · Perez-Cullell N.b · Estelrich J.b · de la Maza A.a · Parra J.L.a
aCID (CSIC), and bFacultat de Farmàcia, Universidad de Barcelona, Barcelona, Spain

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: 8/16/1999
Issue release date: September–October 1999

Number of Print Pages: 12
Number of Figures: 6
Number of Tables: 3

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

The present work deals with the ‘in vivo’ stripping technique to evaluate the percutaneous absorption of sodium fluorescein (NaFl) vehiculized in two different liposome preparations formed by phosphatidylcholine (PC) and lipids mimicking the stratum corneum (SC; ceramides, cholesterol, palmitic acid and cholesteryl sulphate), respectively. Furthermore, the possible effect of these vesicles on the SC lipid alkyl chain conformational order were evaluated at different depths of SC by non-invasive biophysical techniques: Corneometer, Tewameter and especially ATR-FTIR. The results of NaFl percutaneous absorption indicate the highest penetration in the case of incorporation in PC liposomes, which could be related to the increase in SC lipid disorder detected by ATR-FTIR, i.e. a decrease in skin barrier function. On the other hand, SC lipid liposomes have been shown to have a higher affinity for SC owing to the high amount of NaFl found in this layer, suggesting a greater reservoir capacity of SC when similar lipid composition formulation is applied. A lipid order increase is observed by infrared spectroscopy, when these types of liposomes are topically applied, resulting in a strong barrier effect. These results could be useful in designing specific liposomal topical applications.


  

Author Contacts

Luisa Coderch
CID (CSIC)
Jordi Girona 18–26
E–08034 Barcelona (Spain)
Tel. +34 93 4006179, Fax +34 93 2045904, E-Mail lcnesl@cid.csic.es

  

Article Information

Received: Received: Dec. 22, 1998
Accepted: April 8, 1999
Number of Print Pages : 12
Number of Figures : 6, Number of Tables : 3, Number of References : 30

  

Publication Details

Skin Pharmacology and Applied Skin Physiology (Journal of Pharmacological and Biophysical Research)
Incorporating ‘Bioengineering and the Skin’; Founded in 1988 by H. Schaefer
Official Journal of the Skin Pharmacology Society (SPS)

Vol. 12, No. 5, Year 1999 (Cover Date: September-October 1999)

Journal Editor: Hans F. Merk, Aachen
ISSN: 1422–2868 (print), 1422–2906 (Online)

For additional information: http://www.karger.com/journals/sph


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: 8/16/1999
Issue release date: September–October 1999

Number of Print Pages: 12
Number of Figures: 6
Number of Tables: 3

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


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