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Vol. 12, No. 5, 1999
Issue release date: September–October 1999
Section title: Original Research Article
Skin Pharmacol Appl Skin Physiol 1999;12:247–256
(DOI:10.1159/000066249)

Penetration of Titanium Dioxide Microparticles in a Sunscreen Formulation into the Horny Layer and the Follicular Orifice

Lademann J. · Weigmann H.-J. · Rickmeyer C. · Barthelmes H. · Schaefer H. · Mueller G. · Sterry W.
aDermatological Clinic, Medical Faculty Charité, Humboldt University Berlin, bLaser and Medicine Technology GmbH Berlin, Germany; cL’Oréal, Paris, France

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: 8/16/1999

Number of Print Pages: 10
Number of Figures: 6
Number of Tables: 1

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

Coated titanium dioxide (TiO2) microparticles are commonly used as UV filter substances in commercial sunscreen products. The penetration of these microparticles into the horny layer and the orifice of the hair follicle was investigated. The distribution of the microparticles in the horny layer was analyzed using the method of tape stripping in combination with spectroscopic measurements. Deeper layers of the stratum corneum were devoid of TiO2 even after repetitive application of sunscreen preparation when analyzing interfollicular areas. Only in the areas of the pilosebaceous orifices could microparticles be identified. The penetration of TiO2 was investigated in histological skin sections. A biopsy was taken from a skin area from which the horny layer had been removed by tape stripping. In isolated areas, a penetration of coated TiO2 into the open part of the follicle was observed. The amount of TiO2 found in a given follicle was less than 1% of the applied total amount of sunscreens. A penetration of microparticles into viable skin tissue could not be detected.


  

Author Contacts

Priv.-Doz. Dr. Juergen Lademann, Humboldt-Universität zu Berlin
Medizinische Fakultät Charité, Klinik für Dermatologie,
Venerologie und Allergologie mit Asthmapoliklinik
D–10098 Berlin (Germany), Tel. +49 30 2802 3578
Fax +49 30 2802 8415, E-Mail juergen.lademann@charite.de

  

Article Information

Received: Received: April 1, 1999
Accepted: April 15, 1999
Number of Print Pages : 10
Number of Figures : 6, Number of Tables : 1, Number of References : 9

  

Publication Details

Skin Pharmacology and Applied Skin Physiology (Journal of Pharmacological and Biophysical Research)
Incorporating ‘Bioengineering and the Skin’; Founded in 1988 by H. Schaefer
Official Journal of the Skin Pharmacology Society (SPS)

Vol. 12, No. 5, Year 1999 (Cover Date: September-October 1999)

Journal Editor: Hans F. Merk, Aachen
ISSN: 1422–2868 (print), 1422–2906 (Online)

For additional information: http://www.karger.com/journals/sph


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: 8/16/1999

Number of Print Pages: 10
Number of Figures: 6
Number of Tables: 1

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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