Arealization of the Neocortex in Mammals: Genetic and Epigenetic Contributions to the PhenotypeKrubitzer L. · Huffman K.J.
University of California, Davis, Center for Neuroscience and Department of Psychology, Davis, Calif., USA
The neocortex is composed of areas that are functionally, anatomically and histochemically distinct. In comparison to most other mammals, humans have an expanded neocortex, with a pronounced increase in the number of cortical areas. This expansion underlies many complex behaviors associated with human capabilities including perception, cognition, language and volitional motor responses. In the following review we consider data from comparative studies as well as from developmental studies to gain insight into the mechanisms involved in arealization, and discuss how these mechanisms may have been modified in different lineages over time to produce the remarkable degree of organizational variability observed in the neocortex of mammals. Because any phenotype is a result of the complex interactions between genotypic influences and environmental factors, we also consider environmental, or epigenetic, contributions to the organization of the neocortex.
University of California, Davis, Center for Neuroscience and
Department of Psychology
1544 Newton Ct., Davis, CA 95616 (USA)
Tel. +1 530-757-8868, Fax +1 530-757-8827
Number of Print Pages : 14
Number of Figures : 6, Number of Tables : 1, Number of References : 105
Brain, Behavior and Evolution
Founded 1968 and continued 1968–1986 by W. Riss, New York, N.Y.
Official Organ of the J.B. Johnston Club
Vol. 55, No. 6, Year 2000 (Cover Date: June 2000)
Journal Editor: Walter Wilczynski, Austin, Tex.
ISSN: 0006–8977 (print), 1421–9743 (Online)
For additional information: http://www.karger.com/journals/bbe