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Vol. 15, No. 1, 2003
Issue release date: December 2002
Section title: Original Research Article
Dement Geriatr Cogn Disord 2003;15:1–5
(DOI:10.1159/000066670)

APOE Genotype, Memory Test Performance, and the Risk of Alzheimer’s Disease in the Canadian Study of Health and Aging

Klages J.D. · Fisk J.D. · Rockwood K.
Departments of aPsychology, bPsychiatry and cMedicine, Dalhousie University, and dDepartment of Psychology, Queen Elizabeth II Health Sciences Centre, Halifax, Canada

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 7/12/2002
Published online: 12/5/2002

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Objective: This study examined the relation between two risks for Alzheimer’s disease (AD): the apolipoprotein (APOE) ε4 allele and poor memory test performance. Methods: In the Canadian Study of Health and Aging (CSHA), a 5-year longitudinal population-based study that screened and followed over 10,000 participants, 2,914 had an initial clinical assessment and 1,624 had APOE genotype testing. All participants were categorized as having no cognitive impairment, cognitive impairment but no dementia, or dementia at both baseline and follow-up. We examined those (n = 209) with a complete neuropsychological assessment at baseline and no evidence of cognitive impairment who had either APOE ε3/ε3 or ε3/ε4 genotypes and who had a clinical consensus diagnosis of either no cognitive impairment or AD at follow-up. Delayed free recall memory was evaluated at CSHA-1 with the Buschke Cued Recall Test (BCRT). Results: The risk of AD at follow-up was increased for participants with an APOE ε3/ε4 genotype when memory test performance was not considered, but logistic regression demonstrated that a model which also considered baseline memory test performance was more predictive of AD. In the more complete model, reduced BCRT free recall scores were associated with an increased risk of AD, whereas the risk associated with the APOE ε3/ε4 genotype was no longer significant. Conclusions: For those with no evidence of cognitive impairment, drawn from a population-based sample of elderly persons, the APOE ε3/ε4 genotype was only associated with an increased risk of AD after 5 years if their memory test performance was relatively poor at baseline. Regardless of the APOE genotype, and in the absence of clinical evidence of cognitive impairment, reduced scores on a test of delayed free recall at baseline was associated with an increased risk of AD after 5 years.


  

Author Contacts

Dr. John D. Fisk
Abbie J. Lane Building
QE II Health Sciences Centre, 5909 Veteran’s Memorial Way
Halifax, Nova Scotia, B3H 2E2 (Canada)
Tel. +1 902 473 2581, Fax +1 902 473 7166, E-Mail john.fisk@cdha.nshealth.ca

  

Article Information

Accepted: July 12, 2002
Number of Figures : 0, Number of Tables : 2, Number of References : 30

  

Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 15, No. 1, Year 2003 (Cover Date: Released December 2002)

Journal Editor: V. Chan-Palay, New York, N.Y.
ISSN: 1420–8008 (print), 1421–9824 (Online)

For additional information: http://www.karger.com/journals/dem


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 7/12/2002
Published online: 12/5/2002

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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