Integrin-Mediated Adhesion and Signaling during Blastocyst ImplantationWang J. · Armant D.R.
Departments of Obstetrics and Gynecology, and Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Mich., USA
Blastocyst implantation in rodents and primates depends on adhesive interactions between trophoblast cells and the endometrial extracellular matrix. As the blastocyst contacts the uterine basal lamina, cells of the trophectoderm become adhesion-competent and conclude their phenotypic conversion from a polarized epithelium to invasive trophoblast cells that anchor the embryo in the uterine wall and eventually infiltrate the endometrium. Trophoblast cells become capable of adhesion to fibronectin as α5β1 integrins traffick to their apical surfaces. While integrin trafficking may be required for trophoblast adhesion to the endometrium, accumulating evidence indicates that, in response to contact with the extracellular matrix, additional molecules must be recruited to the apical surface before strong adhesion is attained. Based on the known interactions of integrins with cytoplasmic regulatory proteins, we propose that extracellular matrix-bound integrins mediate intracellular signaling cascades that strengthen their adhesive activity. We will review some of the known integrin signaling pathways that could regulate trophoblast adhesion and differentiation.
© 2002 S. Karger AG, Basel
D. Randall Armant
C. S. Mott Center for Human Growth and Development
Department of Obstetrics and Gynecology, Wayne State University School of Medicine
275 E. Hancock Ave., Detroit, MI 48201 (USA)
Tel. +1 313 577 1748, Fax +1 313 577 8554, E-Mail D.Armant@wayne.edu
Number of Figures : 2, Number of Tables : 1, Number of References : 114
Cells Tissues Organs (in vivo, in vitro)
Founded 1945 as Acta Anatomica
Vol. 172, No. 3, Year 2002 (Cover Date: 2002)Formerly Acta Anatomica
Journal Editor: H.-W. Denker, Essen; A.W. English, Atlanta, Ga.
ISSN: 1422–6405 (print), 1422–6421 (Online)
For additional information: http://www.karger.com/journals/cto