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Table of Contents
Vol. 172, No. 3, 2002
Issue release date: 2002
Section title: Paper
Cells Tissues Organs 2002;172:190–201
(DOI:10.1159/000066970)

Integrin-Mediated Adhesion and Signaling during Blastocyst Implantation

Wang J. · Armant D.R.
Departments of Obstetrics and Gynecology, and Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Mich., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 5/25/2001
Accepted: 9/7/2001
Published online: 12/18/2002
Issue release date: 2002

Number of Print Pages: 12
Number of Figures: 2
Number of Tables: 1

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: http://www.karger.com/CTO

Abstract

Blastocyst implantation in rodents and primates depends on adhesive interactions between trophoblast cells and the endometrial extracellular matrix. As the blastocyst contacts the uterine basal lamina, cells of the trophectoderm become adhesion-competent and conclude their phenotypic conversion from a polarized epithelium to invasive trophoblast cells that anchor the embryo in the uterine wall and eventually infiltrate the endometrium. Trophoblast cells become capable of adhesion to fibronectin as α5β1 integrins traffick to their apical surfaces. While integrin trafficking may be required for trophoblast adhesion to the endometrium, accumulating evidence indicates that, in response to contact with the extracellular matrix, additional molecules must be recruited to the apical surface before strong adhesion is attained. Based on the known interactions of integrins with cytoplasmic regulatory proteins, we propose that extracellular matrix-bound integrins mediate intracellular signaling cascades that strengthen their adhesive activity. We will review some of the known integrin signaling pathways that could regulate trophoblast adhesion and differentiation.

© 2002 S. Karger AG, Basel


  

Author Contacts

D. Randall Armant
C. S. Mott Center for Human Growth and Development
Department of Obstetrics and Gynecology, Wayne State University School of Medicine
275 E. Hancock Ave., Detroit, MI 48201 (USA)
Tel. +1 313 577 1748, Fax +1 313 577 8554, E-Mail D.Armant@wayne.edu

  

Article Information

Number of Figures : 2, Number of Tables : 1, Number of References : 114

  

Publication Details

Cells Tissues Organs (in vivo, in vitro)
Founded 1945 as Acta Anatomica

Vol. 172, No. 3, Year 2002 (Cover Date: 2002)

Formerly Acta Anatomica

Journal Editor: H.-W. Denker, Essen; A.W. English, Atlanta, Ga.
ISSN: 1422–6405 (print), 1422–6421 (Online)

For additional information: http://www.karger.com/journals/cto


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 5/25/2001
Accepted: 9/7/2001
Published online: 12/18/2002
Issue release date: 2002

Number of Print Pages: 12
Number of Figures: 2
Number of Tables: 1

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: http://www.karger.com/CTO


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