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Vol. 83, No. 1, 2003
Issue release date: January 2003
Section title: Original Paper
Biol Neonate 2003;83:22–24
(DOI:10.1159/000067012)

Exposure to Di(2-ethylhexyl)phthalate in Humans during Pregnancy

A Preliminary Report

Latini G.a · De Felice C.b · Presta G.a · Del Vecchio A.a · Paris I.c · Ruggieri F.c · Mazzeo P.c
aNeonatal Intensive Care Unit, Division of Pediatrics, Ospedale Perrino, Azienda Ospedaliera A. Di Summa, Brindisi; bNeonatal Intensive Care Unit, Department of Pediatrics, Obstetrics, and Reproductive Medicine University of Siena, and cDepartment of Chemistry, Chemical Engineering and Materials, University of L’Aquila, Coppito/L’Aquila, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/22/2002
Published online: 1/17/2003
Issue release date: January 2003

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO

Abstract

Background: Di(2-ethylhexyl)phthalate (DEHP), the most commonly used plasticizer, is a widespread ubiquitous environmental contaminant. The potential health hazards from exposure to DEHP and its main metabolite, mono(2-ethylhexyl)phthalate (MEHP), have been well documented. Exposure to DEHP and MEHP in humans at risk, such as pregnant women and human fetuses, has not been tested. Methods: Plasma DEHP and MEHP concentrations were measured in a total of 24 consecutive mother-infant pairs by high performance liquid chromatography. Associations between DEHP/MEHP and infant characteristics were tested using Fisher’s exact test, unpaired t tests and univariate linear regression analysis. Results: Measurable DEHP and MEHP concentrations were found in 17/24 (70.8%) and 18/24 (75%) maternal plasmas, respectively, and in 11/25 (44%) and 18/25 (72.0%) cord samples, respectively. Either DEHP or MEHP were detectable in 21/24 (87.5%) maternal plasmas and 19/25 (76%) cord samples. The mean DEHP concentrations in maternal and cord plasmas were 1.15 ± 0.81 and 2.05 ± 1.47 µg/ml, respectively. The mean MEHP concentrations were 0.68 ± 0.85 and 0.68 ± 1.03 µg/ml, respectively. No significant correlations were found between maternal and cord blood DEHP, maternal and cord blood MEHP, maternal DEHP and cord blood MEHP, or maternal MEHP and cord blood DEHP plasma concentrations. Conclusion: Although the effects of perinatal exposure to phthalates need further research, our findings: (i) confirm the high frequency of DEHP and/or MEHP exposure in human pregnancies; (ii) indicate that the exposure to these environmental contaminants begins during intrauterine life, and (iii) suggest that fetal exposure is closely related to the maternal exposure.

© 2003 S. Karger AG, Basel


  

Article Information

Number of Figures : 0, Number of Tables : 0, Number of References : 19

  

Publication Details

Biology of the Neonate (Foetal and Neonatal Research)

Vol. 83, No. 1, Year 2003 (Cover Date: Released January 2003)

Journal Editor: J.P. Relier, Paris
ISSN: 0006–3126 (print), 1421–9727 (Online)

For additional information: http://www.karger.com/bon


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/22/2002
Published online: 1/17/2003
Issue release date: January 2003

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


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