Journal Mobile Options
Table of Contents
Vol. 22, No. 1, 2003
Issue release date: January–February 2003
Section title: Original Paper
Neuroepidemiology 2003;22:13–22
(DOI:10.1159/000067109)

Risk Factors for Dementia in the Cardiovascular Health Cognition Study

Kuller L.H. · Lopez O.L. · Newman A. · Beauchamp N.J. · Burke G. · Dulberg C. · Fitzpatrick A. · Fried L. · Haan M.N.
aDepartment of Epidemiology, University of Pittsburgh Graduate School of Public Health, and bDepartment of Neurology and cDivision of Geriatric Medicine, University of Pittsburgh, Pittsburgh, Pa.; dNeuroradiology Division, Johns Hopkins Radiology, and eThe Johns Hopkins Medical Institutions, Baltimore, Md.; fDepartment of Public Health Sciences, WFU School of Medicine, Winston-Salem, N.C.; Departments of gBiostatistics and hEpidemiology, University of Washington, Seattle, Wash., and iDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Mich., USA

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Automatic perpetual access to all articles of the subscribed year(s)
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 1/13/2003

Number of Print Pages: 10
Number of Figures: 1
Number of Tables: 5

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED

Abstract

Background: The Cardiovascular Health Cognition Study has evaluated the determinants of dementia among 3,608 participants that had a magnetic resonance imaging (MRI) of the brain in 1991 and were followed to 1998–1999. Methods: There were 480 incident dementia cases, 330 (69%) were classified as Alzheimer’s disease (AD). Results: In univariate analysis, low scores on the Modified Mini-Mental State Examination (3MSE) and on the Digit Symbol Substitution Test as well as declines in scores over time prior to the development of dementia were significant predictors of dementia. A high ventricular grade on the MRI (atrophy) as well as high white matter grade, a number of brain infarcts on the MRI were all determinants of dementia. Apolipoprotein E ε4 (ApoE-4) was also a powerful predictor of dementia. In a multivariate Cox proportional hazards model controlling for race, gender and grade, the hazard ratios for age (1.1), 3MSE score (0.9), ventricular size (1.4), white matter grade (1.8), presence of large infarcts >3 mm (1.3) and ApoE-4 (2.1) were significant predictors of dementia. The combination of an ApoE-4 genotype, 3MSE score <90, ≧5 ventricular grade, ≧3 white matter grade at the time of the MRI were associated with a 17-fold increased risk (95% CI: 8.6–34.9) of dementia as compared to individuals with none of the above attributes. Conclusions: Measures of cognition, ApoE-4 and MRI of the brain are strong predictors of both dementia and of AD.


  

Author Contacts

Dr. Lewis H. Kuller
University of Pittsburgh, GSPH, Department of Epidemiology
130 DeSoto Street, A526
Pittsburgh, PA 15261 (USA)
Tel. +1 412 624 3054, Fax +1 412 624 7397, E-Mail kuller@pitt.edu

  

Article Information

Number of Figures : 1, Number of Tables : 5, Number of References : 38

  

Publication Details

Neuroepidemiology
Founded 1982 by B.S. Schoenberg, continued by M. Alter (1989–1996)

Vol. 22, No. 1, Year 2003 (Cover Date: January-February 2003)

Journal Editor: G.C. Román, San Antonio, Tex.
ISSN: 0251–5350 (print), 1423–0208 (Online)

For additional information: http://www.karger.com/journals/ned


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 1/13/2003

Number of Print Pages: 10
Number of Figures: 1
Number of Tables: 5

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.