Accumulating evidence indicates that serine/threonine (Ser/Thr) protein phosphatases (PPs), such as PP1, PP2A and PP2B, participate in the neurodegenerative progress in Alzheimer’s disease (AD). The general characteristics and pathologic changes of PP1, PP2A and PP2B in AD, and their relations with microtubule-associated proteins, focusing mainly on τ protein, neurofilament (NF), amyloid precursor protein (APP) processing and synaptic plasticity are discussed. Deriving novel insight into the particular topic will attract greater attention to more active investigation and effective therapeutic intervention in the future.
Dr. JianZhi Wang
Tongji Medical College
Huazhong University of Science and Technology
Wuhan 430030 (PR China)
Tel. +86 27 83692625, Fax +86 27 83693883, E-Mail email@example.com
Number of Figures : 1, Number of Tables : 1, Number of References : 96
Founded 1992 as ‘Biological Signals’ by S.F. Pang (1992–2001) continued as ‘Biological Signals and Receptors’ (1999–2001)
Vol. 11, No. 5, Year 2002 (Cover Date: September-October 2002)
Journal Editor: Nancy Y. Ip, Hong Kong
ISSN: 1424–862X (print), 1424–8638 (Online)
For additional information: http://www.karger.com/journals/nsg
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