Journal Mobile Options
Table of Contents
Vol. 216, No. 6, 2002
Issue release date: November–December 2002
Section title: Original Paper · Travail original · Originalarbeit
Ophthalmologica 2002;216:455–458
(DOI:10.1159/000067549)

Effects of Sildenafil Citrate (Viagra) on Choroidal Congestion

McCulley T.J. · Luu J.K. · Marmor M.F. · Feuer W.J.
aThe University of California, Irvine; Department of Ophthalmology, Irvine, Calif., bStanford University School of Medicine, Department of Ophthalmology, Stanford, Calif., cBascom Palmer Eye Institute, Miami, Fla., USA

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 33.00
Account: USD 23.00

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Automatic perpetual access to all articles of the subscribed year(s)
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Original Paper · Travail original · Originalarbeit

Received: 4/12/2002
Accepted: 8/23/2002
Published online: 1/10/2003

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)

For additional information: http://www.karger.com/OPH

Abstract

This study evaluates the effect of sildenafil on choroidal vascular congestion and its correlation with visual effects. Thirteen healthy subjects were randomized to a sildenafil group (n = 7, 3 M, 4 F), who received 200 mg of sildenafil, and a control (n = 6, 5 F, 1 M) group, who received no drug. Measurements of choroidal thickness with ultrasonography, color vision with Desaturated Panel D-15 Test, and contrast sensitivity with CSV-1000e charts (Vector Vision) were performed at baseline and at 90 and 180 min. Mean choroidal thickness and contrast sensitivity did not change significantly relative to baseline in either group. However, the variance in differences between repeat and baseline measurements of choroidal thickness was significantly higher at 90 min (p = 0.003) in the sildenafil subjects. Color discrimination error scores increased after sildenafil but did not correlate with changes in choroidal thickness. An oral dose of 200 mg of sildenafil caused small inconsistent changes in choroidal thickness, which did not correlate with visual effects.


  

Author Contacts

Timothy J. McCulley, MD
University of California, Dept. of Ophthalmology
118 Med Surge I
Irvine, CA 92697-4375 (USA)
Tel. +1 949 824 9276, Fax +1 949 824 7645, E-Mail tmcculle@uci.edu

  

Article Information

Received: Received: April 12, 2002
Accepted after revision: August 23, 2002
Number of Figures : 0, Number of Tables : 0, Number of References : 16

  

Publication Details

Ophthalmologica (International Journal of Ophthalmology)
Founded 1899 as ‘Zeitschrift für Augenheilkunde’ by H. Kuhnt and J. von Michel

Vol. 216, No. 6, Year 2002 (Cover Date: November-December 2002)

Journal Editor: Ch. Ohrloff, Frankfurt a.M.
ISSN: 0030–3755 (print), 1423–0267 (Online)

For additional information: http://www.karger.com/oph


Article / Publication Details

First-Page Preview
Abstract of Original Paper · Travail original · Originalarbeit

Received: 4/12/2002
Accepted: 8/23/2002
Published online: 1/10/2003

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)

For additional information: http://www.karger.com/OPH


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.