Effects of Sildenafil Citrate (Viagra) on Choroidal CongestionMcCulley T.J. · Luu J.K. · Marmor M.F. · Feuer W.J.
aThe University of California, Irvine; Department of Ophthalmology, Irvine, Calif., bStanford University School of Medicine, Department of Ophthalmology, Stanford, Calif., cBascom Palmer Eye Institute, Miami, Fla., USA
This study evaluates the effect of sildenafil on choroidal vascular congestion and its correlation with visual effects. Thirteen healthy subjects were randomized to a sildenafil group (n = 7, 3 M, 4 F), who received 200 mg of sildenafil, and a control (n = 6, 5 F, 1 M) group, who received no drug. Measurements of choroidal thickness with ultrasonography, color vision with Desaturated Panel D-15 Test, and contrast sensitivity with CSV-1000e charts (Vector Vision) were performed at baseline and at 90 and 180 min. Mean choroidal thickness and contrast sensitivity did not change significantly relative to baseline in either group. However, the variance in differences between repeat and baseline measurements of choroidal thickness was significantly higher at 90 min (p = 0.003) in the sildenafil subjects. Color discrimination error scores increased after sildenafil but did not correlate with changes in choroidal thickness. An oral dose of 200 mg of sildenafil caused small inconsistent changes in choroidal thickness, which did not correlate with visual effects.
Timothy J. McCulley, MD
University of California, Dept. of Ophthalmology
118 Med Surge I
Irvine, CA 92697-4375 (USA)
Tel. +1 949 824 9276, Fax +1 949 824 7645, E-Mail email@example.com
Received: Received: April 12, 2002
Accepted after revision: August 23, 2002
Number of Figures : 0, Number of Tables : 0, Number of References : 16
Ophthalmologica (International Journal of Ophthalmology)
Founded 1899 as ‘Zeitschrift für Augenheilkunde’ by H. Kuhnt and J. von Michel
Vol. 216, No. 6, Year 2002 (Cover Date: November-December 2002)
Journal Editor: Ch. Ohrloff, Frankfurt a.M.
ISSN: 0030–3755 (print), 1423–0267 (Online)
For additional information: http://www.karger.com/oph