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Table of Contents
Vol. 216, No. 6, 2002
Issue release date: November – December
Section title: Original Paper · Travail original · Originalarbeit
Ophthalmologica 2002;216:399–405
(DOI:10.1159/000067551)

Human Cerebellar Activation in Relation to Saccadic Eye Movements: A Functional Magnetic Resonance Imaging Study

Hayakawa Y.a · Nakajima T.b · Takagi M.a,c · Fukuhara N.b · Abe H.a
aDivision of Ophthalmology and Visual Science, Graduated School of Medicine and Dental Science, Niigata University, and bDepartment of Neurology, National Saigata Hospital, Niigata, cCREST, Japan Science and Technology, Tokyo, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper · Travail original · Originalarbeit

Received: March 19, 2002
Accepted: August 23, 2002
Published online: January 10, 2003
Issue release date: November – December

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 1

ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)

For additional information: http://www.karger.com/OPH

Abstract

Purpose: The functional organization of the human cerebellum involved in saccadic eye movements was investigated using functional magnetic resonance imaging (fMRI). Methods: The subjects were 7 normal volunteers aged 18–34 years. Visual stimuli were back-projected onto a screen placed at the subjects’ feet. The stimulation period of 30 s consisted of a saccade target jumping back and forth horizontally by 20° once per second. The control period of 30 s consisted of a fixed target. The stimulation and control periods were alternated 10 times during the presentation. Functional images were collected with a 1.5-tesla clinical MRI scanner. The significance of activation was determined by Statistical Parametric Mapping (SPM 99) at a threshold of p < 0.001 (uncorrected), and significantly activated areas were superimposed on the T1-weighted images. Results: Significantly activated areas related to visually guided saccades were observed in the cerebellar vermis (declive and folium), in the bilateral cerebellar hemispheres (mainly the superior semilunar lobule) of the cerebellum, in the frontal eye field, in the supplementary eye field and in parts of the parietal lobule of the cerebrum. Conclusion: Our results suggest that the cerebellar posterior vermis and bilateral hemispheres are related to saccades in humans. These results are consistent with neurophysiological data obtained in primates.

© 2002 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper · Travail original · Originalarbeit

Received: March 19, 2002
Accepted: August 23, 2002
Published online: January 10, 2003
Issue release date: November – December

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 1

ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)

For additional information: http://www.karger.com/OPH


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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