Enhanced Pedigree Error DetectionSun L. · Wilder K. · McPeek M.S.
Departments of aStatistics, bMathematics, and cHuman Genetics, University of Chicago, Chicago, Ill., USA; dPresent affiiliation: Department of Public Health Sciences, University of Toronto, and Hospital for Sick Children, Toronto, Canada
Accurate information on the relationships among individuals in a study is critical for valid linkage analysis. We extend the MLLR, EIBD, AIBS and IBS tests for detection of misspecified relationships to a broader range of relative pairs, and we improve the two-stage screening procedure for analyzing large data sets. We have developed software, PREST, which calculates the test statistics and performs the corresponding hypothesis tests for relationship misclassification in general outbred pedigrees. When a potential pedigree error is detected, our companion program, ALTERTEST, can be used to determine which relationships are compatible with the genotype data. Both programs are now freely available on the web.
Department of Public Health Sciences, University of Toronto
12 Queen’s Park Crescent West
Toronto, ON M5S 1A8 (Canada)
Tel. +1 416 978 7519, Fax +1 416 978 8299, E-Mail firstname.lastname@example.org
Received: Received: December 12, 2001
Revision received: October 4, 2002
Accepted: October 7, 2002
Number of Figures : 1, Number of Tables : 6, Number of References : 21
Human Heredity (International Journal of Human and Medical Genetics)
Founded 1950 as Acta Genetica et Statistica Medica by Gunnar Dahlberg; Continued by M. Hauge (1965–1983)
Vol. 54, No. 2, Year 2002 (Cover Date: Released January 2002)
Journal Editor: J. Ott, New York, N.Y.
ISSN: 0001–5652 (print), 1423–0062 (Online)
For additional information: http://www.karger.ch/journals/hhe