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Original Paper

Self-Administration of both Ethanol and Nicotine in Rats

Marshall C.E.a · Dadmarz M.a · Hofford J.M.b · Gottheil E.c · Vogel W.H.a

Author affiliations

aDepartments of Biochemistry and Molecular Pharmacology and Psychiatry and Human Behavior, bDepartment of Medicine, and cDepartment of Psychiatry and Human Behavior, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pa., USA

Related Articles for ""

Pharmacology 2003;67:143–149

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 02, 2002
Accepted: August 01, 2002
Published online: February 17, 2003
Issue release date: March 2003

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 4

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA

Abstract

Self-administration of either nicotine (NIC) or ethanol (ETH) has been extensively studied. This study addressed for the first time the self-administration of both substances when offered together. Male and female rats of different ages were offered NIC and ETH using the two- or three-bottle free-choice method. When NIC and ETH were offered together at different concentrations to young male rats (about 45 days old), intake of NIC increased with increasing NIC concentrations, and intake of ETH increased with decreasing ETH concentrations, but these effects were independent of the presence of the second drug. These rats also consumed the same amounts of NIC or ETH regardless of whether offered individually or together. A prior choice of only NIC or ETH did not affect a subsequent intake of both drugs offered together. A choice of both drugs for 24 h for several days followed by a choice for only 2 h for several days showed the same intake of NIC but a decreased intake of ETH for the shorter period. Young female rats (about 45 days old) and older male rats (about 75 days old) consumed the same amounts of NIC but less ETH than did the young male rats. These results show that young male rats voluntarily consume NIC and ETH independently of each other and that preexposure to one drug does not affect the subsequent intake of both drugs in combination. The data also suggest that these drugs act on different reward centers which have to be ‘satisfied’ independently of each other.

© 2003 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 02, 2002
Accepted: August 01, 2002
Published online: February 17, 2003
Issue release date: March 2003

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 4

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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