Acne in Infancy and Acne GeneticsHerane M.I. · Ando I.
aDepartment of Dermatology, West Unit Faculty of Medicine, Hospital San Juan de Dios, University of Chile, Santiago, Chile; bDepartment of Dermatolgy, Teikyo University, Mizonokuchi Hospital, Kawasaki, Japan
Acne is a disease that can be seen in the first year of age, early childhood, prepubertal age and puberty. Neonatal acne is due mainly to considerable sebum excretion rate, and infantile acne because of high androgens of adrenal origin in girls and of adrenal and testes in boys. These pathogenic mechanisms are characteristic in these ages. Important factors like early onset of comedones and high serum levels of dehydroepiandrosterone sulfate are predictors of severe or long-standing acne in prepubertal age. Hereditary factors play an important role in acne. Neonatal, nodulocystic acne and conglobate acne has proven genetic influences. Postadolescent acne is related with a first-degree relative with the condition in 50% of the cases. Chromosomal abnormalities, HLA phenotypes, polymorphism of human cytochrome P-450 1A1 and MUC1 gene are involved in the pathogenesis of acne. Several other genes are being studied.
Prof. Maria Isabel Herane
Department of Dermatology, West Unit, Hospital San Juan de Dios
Guardia Vieja 255 of. 901
Providencia, Santiago (Chile)
Tel. +56 2 331 04 49, Fax +31 2 331 04 50, E-Mail firstname.lastname@example.org
Number of Figures : 0, Number of Tables : 0, Number of References : 44
Dermatology (International Journal for Clinical and Investigative Dermatology)
Founded as ‘Dermatologische Zeitschrift’ by Oskar Lassar (1893–1907); Continued by Erich Hoffmann (1908–1938), continued as ‘Dermatologica’ (1939–1991), by Wilhelm Lutz (1939–1958), Rudolf Schuppli (1959–1985)
Official Organ of the Swiss Society for Dermatology and Venereology; Official Organ of the Belgian Royal Society for Dermatology and Venereology
Vol. 206, No. 1, Year 2003 (Cover Date: 2003)
Journal Editor: J.-H. Saurat, Geneva.
ISSN: 1018–8665 (print), 1421–9832 (Online)
For additional information: http://www.karger.com/journals/drm