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Table of Contents
Vol. 21, No. 1, 2003
Issue release date: 2003
Section title: Paper
Blood Purif 2003;21:79–84
(DOI:10.1159/000067860)

Sorbents in Acute Renal Failure and the Systemic Inflammatory Response Syndrome

Winchester J.F. · Kellum J.A. · Ronco C. · Brady J.A. · Quartararo P.J. · Salsberg J.A. · Levin N.W.
aRenalTech International, New York, N.Y.; bUniversity of Pittsburgh Medical Center, Pittsburgh, Pa., cRenal Research Institute, New York, N.Y., USA, and dOspedale San Bortolo, Vicenza, Italy

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 1/22/2003

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: http://www.karger.com/BPU

Abstract

Renal replacement therapy in acute renal failure is currently focused on the use of modifications of dialysis (continuous arteriovenous hemofiltration and hemodiafiltration) to remove middle molecular weight toxins, consisting of small proteins, and cytokines involved in the systemic inflammatory response syndrome (SIRS). Conventional high-flux dialyzers are not efficient at removing these molecules, prompting the investigation of sorbents to augment or replace dialysis. Sorbents have been developed to modulate SIRS by targeting cytokines such as IL-1, IL-6, IL-10, IL-18 and TNF, among others. Extensive pre-clinical studies are underway to demonstrate the clinical utility and safety of either adding sorbent hemoadsorption devices to hemodialysis, or the use of such devices alone in SIRS, sepsis, acute renal failure, cardiopulmonary bypass and end-stage renal disease.


  

Author Contacts

James F. Winchester
RenalTech International, LLC
320 East 65th Street, #117
New York, NY 10021 (USA)
Tel. +1 212 717 8644, Fax +1 212 717 8643, E-Mail jamesw@renaltech.com

  

Article Information

Number of Figures : 2, Number of Tables : 2, Number of References : 37

  

Publication Details

Blood Purification
Founded 1983; edited by K. Schaefer (1983–1988)
Official Journal of the International Society of Blood Purification and the Vascular Access Society (VAS)

Vol. 21, No. 1, Year 2003 (Cover Date: 2003)

Journal Editor: K.M.L. Leunissen, Maastricht
ISSN: 0253–5068 (print), 1421–9735 (Online)

For additional information: http://www.karger.com/bpu


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 1/22/2003

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: http://www.karger.com/BPU


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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