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Table of Contents
Vol. 15, No. 2, 2003
Issue release date: January 2003
Section title: Original Research Article
Dement Geriatr Cogn Disord 2003;15:55–66
(DOI:10.1159/000067968)

Dopaminergic Modulation of Visual-Spatial Working Memory in Parkinson’s Disease

Costa A.a · Peppe A.a · Dell’Agnello G.c · Carlesimo G.A.a,b · Murri L.c · Bonuccelli U.c · Caltagirone C.a,b
aIRCCS, Fondazione Santa Lucia, e bClinica Neurologica, Università di Roma ‘Tor Vergata’, Roma, e cDipartimento di Neuroscience, Clinica Neurologica, Università di Pisa, Italia

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: August 19, 2002
Published online: January 20, 2003
Issue release date: January 2003

Number of Print Pages: 12
Number of Figures: 5
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Visual-spatial working memory (WM) impairment is frequently associated with the early stage of Parkinson’s disease (PD). The aim of this study was to evaluate the performance of a group of PD patients in visual-spatial and visual-object WM tasks and to investigate the effect of administering the dopaminergic agonist apomorphine (experiment 1) or the dopamine precursor L-dopa (experiment 2) on the performance of tests assessing these functions. To study WM processes, the PD patients and age-matched normal controls were given an n-back task paradigm. In both experiments, the PD patients were submitted to two evaluations: one after a 12-hour therapy washout and the other 15 min after a subcutaneous infusion of apomorphine (average 0.04 mg/kg) or 20/30 min after L-dopa intake (200 mg p.o.). The apomorphine infusion had a worsening effect on reaction times in both visual-spatial and visual-object WM tasks, but it did not influence performance accuracy. Instead, L-dopa administration had a ameliorative effect on accuracy and reaction times in both visual-spatial and visual-object tasks. These results highlight the role of dopamine in the modulation of the WM function in PD patients.

© 2003 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: August 19, 2002
Published online: January 20, 2003
Issue release date: January 2003

Number of Print Pages: 12
Number of Figures: 5
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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