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Vol. 15, No. 2, 2003
Issue release date: January 2003
Section title: Original Research Article
Dement Geriatr Cogn Disord 2003;15:55–66
(DOI:10.1159/000067968)

Dopaminergic Modulation of Visual-Spatial Working Memory in Parkinson’s Disease

Costa A. · Peppe A. · Dell’Agnello G. · Carlesimo G.A. · Murri L. · Bonuccelli U. · Caltagirone C.
aIRCCS, Fondazione Santa Lucia, e bClinica Neurologica, Università di Roma ‘Tor Vergata’, Roma, e cDipartimento di Neuroscience, Clinica Neurologica, Università di Pisa, Italia

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 8/19/2002
Published online: 1/20/2003

Number of Print Pages: 12
Number of Figures: 5
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Visual-spatial working memory (WM) impairment is frequently associated with the early stage of Parkinson’s disease (PD). The aim of this study was to evaluate the performance of a group of PD patients in visual-spatial and visual-object WM tasks and to investigate the effect of administering the dopaminergic agonist apomorphine (experiment 1) or the dopamine precursor L-dopa (experiment 2) on the performance of tests assessing these functions. To study WM processes, the PD patients and age-matched normal controls were given an n-back task paradigm. In both experiments, the PD patients were submitted to two evaluations: one after a 12-hour therapy washout and the other 15 min after a subcutaneous infusion of apomorphine (average 0.04 mg/kg) or 20/30 min after L-dopa intake (200 mg p.o.). The apomorphine infusion had a worsening effect on reaction times in both visual-spatial and visual-object WM tasks, but it did not influence performance accuracy. Instead, L-dopa administration had a ameliorative effect on accuracy and reaction times in both visual-spatial and visual-object tasks. These results highlight the role of dopamine in the modulation of the WM function in PD patients.


  

Author Contacts

Alberto Costa
Fondazione IRCCS Santa Lucia
Via Ardeatina, 306
I–00179 Rome (Italy)
Tel./Fax +39 06 51501584, E-Mail memolab@hsantalucia.it

  

Article Information

Accepted: August 19, 2002
Number of Figures : 5, Number of Tables : 2, Number of References : 60

  

Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 15, No. 2, Year 2003 (Cover Date: Released January 2003)

Journal Editor: V. Chan-Palay, New York, N.Y.
ISSN: 1420–8008 (print), 1421–9824 (Online)

For additional information: http://www.karger.com/journals/dem


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 8/19/2002
Published online: 1/20/2003

Number of Print Pages: 12
Number of Figures: 5
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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