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Vol. 46, Suppl. 1, 2002
Issue release date: January 2003
Section title: Paper
Neuropsychobiology 2002;46(suppl 1):16–21
(DOI:10.1159/000068016)

Neuropsychological Performance in Depressed and Euthymic Bipolar Patients

Martinez-Aran A. · Vieta E. · Colom F. · Reinares M. · Benabarre A. · Torrent C. · Goikolea J.M. · Corbella B. · Sánchez-Moreno J. · Salamero M.
Bipolar Disorders Program, Clinical Institute of Psychiatry and Psychology, Hospital Clinic, Barcelona Stanley Medical Institute Research Center, University of Barcelona, Barcelona, Spain

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 2/12/2003

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

Introduction: Recent studies have suggested that the presence of persistent cognitive dysfunctions in bipolar patients is not restricted to acute episodes, but they persist even during remission states. Nevertheless, there are several methodological pitfalls in most studies, such as unclear remission criteria, diagnostic heterogeneity or small sample sizes. Patients and Methods: Several domains of cognitive function were examined in 30 depressed bipolar patients [DSM-IV criteria for major depression, Hamilton Depression Scale (HDRS) ≧17] and 30 euthymic bipolar patients (at least 6 months of remission, HDRS ≤8 and Young Mania Rating Scale, YMRS ≤6). Psychosocial functioning was assessed through General Assessment of Functioning. Results: The two groups showed a similar pattern of neuropsychological performance. However, the depressed group was significantly impaired on the Controlled Oral Word Association Test, FAS (COWAT), a measure of verbal fluency, compared with the euthymic group. On the other hand, functional outcome in euthymic patients was related to verbal fluency, even after controlling for residual depressive symptoms. Conclusions: Neuropsychological performance was similar in both groups, except for verbal fluency, which was lower in the depressed group. Poor verbal fluency was related to a poor social outcome in euthymic patients. Further research including longitudinal designs aimed at evaluating changes in cognition in these patients is warranted.


  

Author Contacts

Eduard Vieta, MD, PhD
Clinical Institute of Psychiatry and Psychology
Hospital Clinic, University of Barcelona
Villarroel 170, E–08036 Barcelona (Spain)
Tel. +34 93 2275401, Fax +34 93 2275477, E-Mail evieta@clinic.ub.es

  

Article Information

Number of Figures : 0, Number of Tables : 2, Number of References : 38

  

Publication Details

Neuropsychobiology (International Journal of Experimental and Clinical Research in Biological Psychiatry, Pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography)
Founded 1975 by J. Mendlewicz (Brussels)
Official Journal of the International Pharmaco-EEG Society (IPEG)

Vol. 46, No. Suppl. 1, Year 2002 (Cover Date: Released January 2003)

Journal Editor: J. Mendlewicz, Brussels; B. Saletu, Vienna; P. Netter, Giessen; W.M. Herrmann, Berlin
ISSN: 0302–282X (print), 1423–0224 (Online)

For additional information: http://www.karger.com/journals/nps


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 2/12/2003

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


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