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Table of Contents
Vol. 99, No. 1, 2003
Issue release date: February 2003
Section title: Coronary Care
Cardiology 2003;99:39–46
(DOI:10.1159/000068445)

Age and Sex Differences in the Treatment of Patients with Initial Acute Myocardial Infarction: A Community-Wide Perspective

Harrold L.R. · Lessard D. · Yarzebski J. · Gurwitz J.H. · Gore J.M. · Goldberg R.J.
Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, Mass., USA

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Article / Publication Details

First-Page Preview
Abstract of Coronary Care

Received: 8/5/2002
Accepted: 10/1/2002
Published online: 2/24/2003

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 3

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD

Abstract

Purpose: The goal of this observational study was to examine overall and age-specific differences between women and men in the use of five beneficial cardiac medications in patients hospitalized with acute myocardial infarction (AMI) from a community-wide perspective. The objectives of our study were to determine whether women are treated differently than men and whether age acts as a potential effect modifier of any observed associations. Subjects: A total of 2,461 women and 3,454 men with validated AMI comprised the study sample. Methods: Our study was an observational investigation of metropolitan Worcester (Mass., USA) residents who were hospitalized with initial AMI in all area hospitals during 12 1-year periods between 1975 and 1999. Four age-specific subgroups (<55, 55–64, 65–74 and ≧75 years) were studied. Results: Differences in the use of angiotensin-converting enzyme (ACE) inhibitors, aspirin, β-blockers, lipid-lowering medications and thrombolytic agents during hospitalization for AMI were examined. The results of a multivariable regression analysis indicated that women were significantly less likely to receive aspirin and ACE inhibitors as compared to men. There were no significant gender differences in the prescribing of the other cardiac medications. Increasing age in both women and men was associated with a reduced likelihood of receiving effective cardiac therapies including aspirin, β-blockers, lipid-lowering therapy and thrombolytic agents. Conclusions: These data suggest that the reasons for the marked age-related differences, in men and women, in the use of cardiac medications be more systematically explored. Previously observed gender differences in the management of patients with AMI essentially no longer exist.


  

Author Contacts

Robert J. Goldberg, PhD
Division of Cardiovascular Medicine, Department of Medicine
University of Massachusetts Medical School
55 Lake Avenue North, Worcester, MA 01655 (USA)
Tel. +1 508 856 4237, Fax +1 508 856 4571, E-Mail GoldberR@ummhc.org

  

Article Information

Received: August 5, 2002
Accepted: October 1, 2002
Number of Figures : 4, Number of Tables : 3, Number of References : 26

  

Publication Details

Cardiology (International Journal of Cardiovascular Medicine, Surgery and Pathology)
Founded 1937 as ‘Cardiologia’ by Bruno Kisch and Wilhelm Löffler

Vol. 99, No. 1, Year 2003 (Cover Date: Released February 2003)

Journal Editor: Joseph S. Alpert, Tucson, Ariz.
ISSN: 0008–6312 (print), 1421–9751 (Online)

For additional information: http://www.karger.com/journals/crd


Article / Publication Details

First-Page Preview
Abstract of Coronary Care

Received: 8/5/2002
Accepted: 10/1/2002
Published online: 2/24/2003

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 3

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


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