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Table of Contents
Vol. 206, No. 2, 2003
Issue release date: 2003
Section title: Clinical and Laboratory Investigations
Dermatology 2003;206:113–119
(DOI:10.1159/000068467)

Chronic Pemphigoid gestationis: Comparative Clinical and Immunopathological Study of 10 Patients

Boulinguez S.a · Bédane C.a · Prost C.b · Bernard P.c · Labbé L.d · Bonnetblanc J.M.a
aDepartment of Dermatology, Hôpital Dupuytren, Limoges, bDepartment of Dermatology, Hôpital Saint-Louis, Paris, cDepartment of Dermatology, Hôpital Robert-Debré, Reims, and dDepartment of Dermatology, Hôpital Pellegrin, Bordeaux, France

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Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigations

Received: December 17, 2001
Accepted: August 08, 2002
Published online: March 10, 2003
Issue release date: 2003

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 3

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Background: Pemphigoid gestationis (PG) is a rare autoimmune bullous disorder occurring during the last trimester of pregnancy and usually regressive within 3 months after delivery. Prolonged forms of the disease lasting more than 6 months after delivery have been reported as chronic PG. Objective: The aim of the present study was to compare the clinical and immunopathological findings between 4 patients presenting a normal regression of the disease after delivery and 6 patients with a chronic course. Methods: All patients were evaluated and studied by clinical patterns (age, mucosal and cutaneous involvement, obstetrical history, duration of the blistering disease and response to treatment), by direct and indirect immunofluorescence and Western blot. Eight patients were studied by immunoelectron microscopy (IEM) and 3 patients had an indirect IEM. Results: Patients with chronic PG were older, had multigravidity, a history of PG during previous pregnancies, widespread cutaneous eruption and mucosal involvement. Subclass analysis of circulating autoantibodies showed an IgG1 anti-BP180 response in all patients except 1 with disease of 7 years’ duration. Direct IEM was positive in 6/8 patients showing a labeling of the lamina lucida, and indirect IEM using colloidal gold probes confirmed the localization of the target antigens to the proximal part of the anchoring filaments in the lamina lucida. Conclusion: This study suggests that, even in chronic long-lasting PG, IgG1 remains the predominant subtype of IgG. Therefore no biological and predictable marker of chronicity can be ascertained from this series.

© 2003 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigations

Received: December 17, 2001
Accepted: August 08, 2002
Published online: March 10, 2003
Issue release date: 2003

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 3

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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