Nonoliguric hyperkalemia of premature infants probably results from a transient inhibition of membrane-bound Na+/K+-ATPase during the first 24 h after birth. We hypothesized that the endogenous digitalis-like activity of the serum of premature infants, which inhibits the Na+/K+-ATPase, triggered hyperkalemia. Serum concentrations of potassium ([K+]) and of the digoxin-like immunoreactive substance ([DLIS]) were measured during the first 24 h after birth in 60 infants including 30 infants <30 gestational weeks. Contrary to our hypothesis, there was a negative linear correlation between [DLIS] at birth and [K+] 24 h after birth (r2 = 0.24, p < 0.002). 24 h after birth there was no correlation between [DLIS] and [K+]. Thus, a major role of DLIS in nonoliguric hyperkalemia could not be established.
Dr. Eva Mildenberger
Kinderklinik, Universitätsklinikum Benjamin Franklin
D–12200 Berlin (Germany)
Tel. +49 30 8445 4112, Fax +49 30 8445 4113, E-Mail firstname.lastname@example.org
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 2, Number of References : 27
Biology of the Neonate (Foetal and Neonatal Research)
Vol. 83, No. 3, Year 2003 (Cover Date: Released April 2003)
Journal Editor: J.P. Relier, Paris
ISSN: 0006–3126 (print), 1421–9727 (Online)
For additional information: http://www.karger.com/bon
Article / Publication Details
Published online: 4/3/2003
Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: http://www.karger.com/NEO
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