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Vol. 83, No. 3, 2003
Issue release date: April 2003
Section title: Original Paper
Biol Neonate 2003;83:182–187
(DOI:10.1159/000068929)

Digoxin-Like Immunoreactive Substance in Nonoliguric Hyperkalemia of the Premature Infant

Mildenberger E. · Oels K. · Bauer K. · Paul M. · Versmold H.T.
Departments of aPediatrics and bClinical Pharmacology, Universitätsklinikum Benjamin Franklin, Berlin, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/18/2002
Published online: 4/3/2003

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO

Abstract

Nonoliguric hyperkalemia of premature infants probably results from a transient inhibition of membrane-bound Na+/K+-ATPase during the first 24 h after birth. We hypothesized that the endogenous digitalis-like activity of the serum of premature infants, which inhibits the Na+/K+-ATPase, triggered hyperkalemia. Serum concentrations of potassium ([K+]) and of the digoxin-like immunoreactive substance ([DLIS]) were measured during the first 24 h after birth in 60 infants including 30 infants <30 gestational weeks. Contrary to our hypothesis, there was a negative linear correlation between [DLIS] at birth and [K+] 24 h after birth (r2 = 0.24, p < 0.002). 24 h after birth there was no correlation between [DLIS] and [K+]. Thus, a major role of DLIS in nonoliguric hyperkalemia could not be established.


  

Author Contacts

Dr. Eva Mildenberger
Kinderklinik, Universitätsklinikum Benjamin Franklin
Hindenburgdamm 30
D–12200 Berlin (Germany)
Tel. +49 30 8445 4112, Fax +49 30 8445 4113, E-Mail eva.mildenberger@ukbf.fu-berlin.de

  

Article Information

Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 2, Number of References : 27

  

Publication Details

Biology of the Neonate (Foetal and Neonatal Research)

Vol. 83, No. 3, Year 2003 (Cover Date: Released April 2003)

Journal Editor: J.P. Relier, Paris
ISSN: 0006–3126 (print), 1421–9727 (Online)

For additional information: http://www.karger.com/bon


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/18/2002
Published online: 4/3/2003

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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