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Vol. 49, No. 3, 2003
Issue release date: March 2003
Section title: Original Paper
Eur Neurol 2003;49:164–168
(DOI:10.1159/000069085)

Extraocular Blood Flow and Endothelin-1 Plasma Levels in Patients with Multiple Sclerosis

Pache M. · Kaiser H.J. · Akhalbedashvili N. · Lienert C. · Dubler B. · Kappos L. · Flammer J.
aUniversity Eye Clinic Basel and bDepartment of Neurology, University Hospital Basel, Basel, Switzerland

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 6/20/2002
Accepted: 11/12/2002
Published online: 3/28/2003

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE

Abstract

In order to evaluate whether plasma levels of the potent vasoconstrictor endothelin-1 (ET-1) are increased in patients with multiple sclerosis (MS) and whether these patients exhibit an ET-1-mediated vascular dysregulation, ET-1 plasma levels were measured in 30 patients with MS. Blood flow velocities in the ophthalmic artery, central retinal artery, central retinal vein, short lateral posterior ciliary artery, and short medial posterior ciliary artery were assessed in parallel. ET-1 plasma levels were significantly increased in MS patients when compared to sex- and age-matched healthy controls (2.0 ± 0.4 pg/ml, range 1.1–2.8 vs. 1.5 ± 0.2 pg/ml, range 0.9–2.0; p < 0.001). Moreover, the patients exhibited significant alterations of extraocular blood flow. The role of ET-1 in the inflammatory process remains to be clarified.


  

Author Contacts

Hedwig J. Kaiser, MD
University Eye Clinic Basel
Mittlere Strasse 91, PO Box
CH–4012 Basel (Switzerland)
Tel. +41 61 265 8722, Fax +41 61 265 8652, E-Mail Hedwig-J.Kaiser@unibas.ch

  

Article Information

Received: June 20, 2002
Accepted: November 12, 2002
Number of Print Pages : 5
Number of Figures : 1, Number of Tables : 1, Number of References : 35

  

Publication Details

European Neurology
Founded 1897 as ‘Monatsschrift für Psychiatrie und Neurologie’

Vol. 49, No. 3, Year 2003 (Cover Date: Released March 2003)

Journal Editor: J. Bogousslavsky, Lausanne
ISSN: 0014–3022 (print), 1421–9913 (Online)

For additional information: http://www.karger.com/journals/ene


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 6/20/2002
Accepted: 11/12/2002
Published online: 3/28/2003

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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